Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women.
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women.
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卵泡液中 ApoE 表达增加和 ApoE 基因型与中国女性子宫内膜异位症相关
DOI：
10.3389/fendo.2021.779183
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发表时间：
2021
影响因子：
5.2
通讯作者：
Cao YX
中科院分区：
文献类型：
--
作者：
Liu YJ;Xing F;Zong K;Wang MY;Ji DM;Zhao YH;Xia YH;Wang A;Shi LG;Ding SM;Wei ZL;Qiao JP;Du X;Cao YX
超过10%的女性在生育期间患有子宫内膜异位症（EMT）。EMT可导致疼痛和不孕，需要从多个角度进行进一步研究。以往的研究表明，载脂蛋白E（ApoE）的增加可能与老年妇女获得成熟卵母细胞的数量减少有关，ApoE与EMT患者的自发性妊娠丢失可能存在相关性。本研究的目的是探讨中国妇女卵泡液中ApoE水平是否升高及其与EMT的关系。在本研究中，217名中国女性（111名对照组和106名EMT患者）被纳入。采用桑格测序法鉴定ApoE基因型。我们发现EMT患者FF中ApoE的表达高于对照组。EMT组与对照组ApoE 4基因携带者（ApoE 3/ApoE 4，ApoE 4/ApoE 4）差异有统计学意义（P < 0. 05）。此外，非参数检验显示，两组之间的囊胚和高质量囊胚的数量存在显著差异，但FSH、LH和E2的激素水平无显著差异。我们还建立了一个多因素（BMI，高质量的囊胚和EMT 4）预测模型，具有良好的灵敏度，用于识别可能患有EMT的患者。我们的研究结果表明，ApoE在FF中的表达在EMT中增加，ApoE-β 4等位基因与EMT显著相关，三个因素（BMI，高质量囊胚和β 4）的联合分析可用作EMT的预测因子。
More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT.
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DOI：
10.1093/gerona/glz232
发表时间：
2020-10-01
影响因子：
5.1
作者：
Dankner, Rachel;Ben Avraham, Sivan;Chetrit, Angela
通讯作者：
Chetrit, Angela
影响因子：
3.4
作者：
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DOI：
10.18502/ijrm.v16i12.3683
发表时间：
2018-12-01
影响因子：
1.3
作者：
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影响因子：
3.7
作者：
van Exel E;Koopman JJE;Bodegom DV;Meij JJ;Knijff P;Ziem JB;Finch CE;Westendorp RGJ
通讯作者：
Westendorp RGJ
影响因子：
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