Characterizing the Influence of Preload Dosing on Percent Signal Recovery (PSR) and Cerebral Blood Volume (CBV) Measurements in a Patient Population With High-Grade Glioma Using Dynamic Susceptibility Contrast MRI.
Characterizing the Influence of Preload Dosing on Percent Signal Recovery (PSR) and Cerebral Blood Volume (CBV) Measurements in a Patient Population With High-Grade Glioma Using Dynamic Susceptibility Contrast MRI.
复制标题
DOI：
10.18383/j.tom.2017.00004
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Quarles CC
中科院分区：
文献类型：
--
作者：
Bell LC;Hu LS;Stokes AM;McGee SC;Baxter LC;Quarles CC
使用DSC-MRI，对比剂泄漏效应在脑肿瘤中既可以用于信号恢复百分比（PSR）测量，也可以用于准确的相对脑血容量（rCBV）测量。在成像和/或特定的后处理步骤之前，可以通过施加预负荷剂量来减少泄漏效应。本研究对14例高级别胶质瘤患者进行回顾性分析，比较了PSR和rCBV测量值的一致性作为不同负荷前剂量的函数。扫描包括6次连续注射（0.05 mmol/kg）期间的6次DSC-MRI扫描。计算肿瘤和正常白质区域的平均PSR。在计算平均肿瘤rCBV之前，对DSC-MRI数据进行了泄漏效应校正。不同预负荷的肿瘤PSR有统计学差异（P值= 4.57E-24）。肿瘤rCBV值在不同的预负荷之间没有统计学上的显著差异（P值= 0.14），并且在临床相关的预负荷之间高度一致（组内相关系数= 0.93）。对于0.05 mmol/kg注射量和脉冲序列参数，在不使用预负荷时，正常白质和肿瘤之间的PSR对比度最高。这表明使用PSR作为生物标志物的研究应该在没有预加载的情况下获取DSC-MRI数据。泄漏校正的rCBV值不依赖于预负荷的存在或剂量，这一发现与先前采用不同获取方案的研究相矛盾。这进一步证实了rCBV对预负荷给药方案和脉冲序列参数的敏感性，并强调了标准化工作对实现多位点rCBV一致性的重要性。
With DSC-MRI, contrast agent leakage effects in brain tumors can either be leveraged for percent signal recovery (PSR) measurements or be adequately resolved for accurate relative cerebral blood volume (rCBV) measurements. Leakage effects can be dimished by administration of a preload dose before imaging and/or specific postprocessing steps. This study compares the consistency of both PSR and rCBV measurements as a function of varying preload doses in a retrospective analysis of 14 subjects with high-grade gliomas. The scans consisted of 6 DSC-MRI scans during 6 sequential bolus injections (0.05 mmol/kg). Mean PSR was calculated for tumor and normal-appearing white matter regions of interest. DSC-MRI data were corrected for leakage effects before computing mean tumor rCBV. Statistical differences were seen across varying preloads for tumor PSR (P value = 4.57E-24). Tumor rCBV values did not exhibit statistically significant differences across preloads (P value = .14) and were found to be highly consistent for clinically relevant preloads (intraclass correlation coefficient = 0.93). For a 0.05 mmol/kg injection bolus and pulse sequence parameters used, the highest PSR contrast between normal-appearing white matter and tumor occurs when no preload is used. This suggests that studies using PSR as a biomarker should acquire DSC-MRI data without preload. The finding that leakage-corrected rCBV values do not depend on the presence or dose of preload contradicts that of previous studies with dissimilar acquisition protocols. This further confirms the sensitivity of rCBV to preload dosing schemes and pulse sequence parameters and highlights the importance of standardization efforts for achieving multisite rCBV consistency.
登录
查看更多内容
影响因子：
3.3
作者：
Newbould, Rexford D.;Skare, Stefan T.;Bammer, Roland
通讯作者：
Bammer, Roland
影响因子：
2.6
作者：
Espagnet, Maria C. Rossi;Romano, Andrea;Bozzao, Alessandro
通讯作者：
Bozzao, Alessandro
影响因子：
3.5
作者：
Boxerman, J. L.;Paulson, E. S.;Schmainda, K. M.
通讯作者：
Schmainda, K. M.
影响因子：
3.3
作者：
Semmineh, Natenael B.;Xu, Junzhong;Skinner, Jack T.;Xie, Jingping;Li, Hua;Ayers, Gregory;Quarles, C. Chad
通讯作者：
Quarles, C. Chad
影响因子：
4.4
作者：
Leu, Kevin;Boxerman, Jerrold L.;Ellingson, Benjamin M.
通讯作者：
Ellingson, Benjamin M.