Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE).
Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE).
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DOI：
10.1002/mrm.25435
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发表时间：
2015-09
影响因子：
3.3
通讯作者：
Quarles, C. Chad
中科院分区：
文献类型：
--
作者：
Semmineh, Natenael B.;Xu, Junzhong;Skinner, Jack T.;Xie, Jingping;Li, Hua;Ayers, Gregory;Quarles, C. Chad
关键词：
在脑肿瘤动态敏感性对比(DSC)-MRI研究中，使用多回波采集方法来量化对比剂(CA)渗出时T1和T2*的动态变化。这种方法还可以估计有效的组织CA横向弛豫度。本研究的目的是评估示踪平衡点的横向弛豫度(TRATE)对肿瘤细胞结构的敏感性。计算和体外研究被用来评估RATE的生物物理基础。比较9L、C6和人脑肿瘤的表观扩散系数(ADC)、CA转移常数(KTrans)、血管外体积分数(Ve)和组织学资料。模拟和体外结果表明，TATE对细胞大小和密度等细胞属性的变化高度敏感。9L肿瘤的组织学细胞密度和RATE值显著高于C6肿瘤。在动物和人类肿瘤中，RATE与ADC、VE和KTRANS图的体素比较显示空间相关性较低。TRATE的评估在临床上是可行的，它对组织细胞结构特征的敏感性是其他成像方法所没有的，表明它可能成为癌症的一个独特的结构特征或“特征”。
In brain tumor dynamic susceptibility contrast (DSC)-MRI studies, multi-echo acquisition methods are used to quantify the dynamic changes in T1 and T2* that occur when contrast agent (CA) extravasates. Such methods also enable the estimation of the effective tissue CA transverse relaxivity. The goal of this study was to evaluate the sensitivity of the Transverse Relaxivity at Tracer Equilibrium (TRATE) to tumor cytoarchitecture. Computational and in vitro studies were used to evaluate the biophysical basis of TRATE. In 9L, C6 and human brain tumors, TRATE, the apparent diffusion coefficient (ADC), the CA transfer constant (Ktrans), the extravascular extracellular volume fraction (ve) and histological data were compared. Simulations and in vitro results indicate that TRATE is highly sensitive to variations in cellular properties such as cell size and density. The histologic cell density and TRATE values were significantly higher in 9L tumors as compared to C6 tumors. In animal and human tumors, a voxel-wise comparison of TRATE with ADC, ve, and Ktrans maps showed low spatial correlation. The assessment of TRATE is clinically feasible and its sensitivity to tissue cytoarchitectural features not present in other imaging methods indicate that it could potentially serve as a unique structural signature or “trait” of cancer.
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