Spontaneous and visually driven high-frequency oscillations in the occipital cortex: intracranial recording in epileptic patients.
Spontaneous and visually driven high-frequency oscillations in the occipital cortex: intracranial recording in epileptic patients.
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DOI：
10.1002/hbm.21233
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发表时间：
2012-03
影响因子：
4.8
通讯作者：
Asano, Eishi
中科院分区：
文献类型：
--
作者：
Nagasawa, Tetsuro;Juhasz, Csaba;Rothermel, Robert;Hoechstetter, Karsten;Sood, Sandeep;Asano, Eishi
关键词：
人类大脑皮层自发产生≥80hz的非癫痫性高频振荡（HFOs）。在10例枕叶外癫痫患者中，我们比较了非癫痫性枕叶皮层自发产生的hfo与由视觉任务驱动的hfo以及枕叶外癫痫灶引起的癫痫性hfo的频谱空间特征。我们发现在间歇慢波睡眠期间，自发性hfo以≥80 Hz的频率，平均持续时间为330 msec，间歇性地从枕叶皮层出现。自发枕骨hfo的频谱频带与视觉驱动hfo相似。自发性枕部hfo在空间上稀疏且局限于较小的区域，而视觉驱动型hfo涉及较大的区域，包括更多的吻侧部位。自发性枕部HFOs的频谱频带和振幅与癫痫性HFOs无显著差异。自发性枕部hfo强烈锁定于δ活动相，但δ相耦合强度在1 ~ 3 Hz范围内衰减。相反，在1 ~ 3hz范围内，致痫性枕外hfo被锁定在δ波活动相上。枕叶皮层自发产生生理性的hfo，这在皮质电图上可能与其他部位产生的病理性hfo一样突出；在术前评估时应考虑到这一观察结果。自发δ波和hfo的耦合可能会增加对慢波睡眠中δ波振荡意义的理解。需要进一步的研究来确定delta-phase耦合是否区分生理性和病理性hfo，或者只是在解剖位置上不同。
High-frequency oscillations (HFOs) at ≧80 Hz of nonepileptic nature spontaneously emerge from human cerebral cortex. In 10 patients with extra-occipital lobe epilepsy, we compared the spectral-spatial characteristics of HFOs spontaneously arising from the nonepileptic occipital cortex with those of HFOs driven by a visual task as well as epileptogenic HFOs arising from the extra-occipital seizure focus. We identified spontaneous HFOs at ≧80 Hz with a mean duration of 330 msec intermittently emerging from the occipital cortex during interictal slow-wave sleep. The spectral frequency band of spontaneous occipital HFOs was similar to that of visually-driven HFOs. Spontaneous occipital HFOs were spatially sparse and confined to smaller areas, whereas visually-driven HFOs involved the larger areas including the more rostral sites. Neither spectral frequency band nor amplitude of spontaneous occipital HFOs significantly differed from those of epileptogenic HFOs. Spontaneous occipital HFOs were strongly locked to the phase of delta activity, but the strength of delta-phase coupling decayed from 1 to 3 Hz. Conversely, epileptogenic extra-occipital HFOs were locked to the phase of delta activity about equally in the range from 1 to 3 Hz. The occipital cortex spontaneously generates physiological HFOs which may stand out on electrocorticography traces as prominently as pathological HFOs arising from elsewhere; this observation should be taken into consideration during presurgical evaluation. Coupling of spontaneous delta and HFOs may increase the understanding of significance of delta-oscillations during slow-wave sleep. Further studies are warranted to determine whether delta-phase coupling distinguishes physiological from pathological HFOs or simply differs across anatomical locations.
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影响因子：
5.7
作者：
Fukuda, Miho;Rothermel, Robert;Juhasz, Csaba;Nishida, Masaaki;Sood, Sandeep;Asano, Eishi
通讯作者：
Asano, Eishi
影响因子：
3
作者：
Dalal, Sarang S.;Edwards, Erik;Kirsch, Heidi E.;Barbaro, Nicholas M.;Knight, Robert T.;Nagarajan, Srikantan S.
通讯作者：
Nagarajan, Srikantan S.
影响因子：
4.7
作者：
Gaetz, W.;Otsubo, H.;Pang, E. W.
通讯作者：
Pang, E. W.
影响因子：
14.5
作者：
Csercsa, Richard;Dombovari, Balazs;Ulbert, Istvan
通讯作者：
Ulbert, Istvan
影响因子：
5.6
作者：
Bagshaw, Andrew P.;Jacobs, Julia;Gotman, Jean
通讯作者：
Gotman, Jean