Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss.
Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss.
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DOI：
10.1016/j.neurobiolaging.2020.08.012
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发表时间：
2020-12
影响因子：
4.2
通讯作者：
Lauer AM
中科院分区：
文献类型：
--
作者：
Kobrina A;Schrode KM;Screven LA;Javaid H;Weinberg MM;Brown G;Board R;Villavisanis DF;Dent ML;Lauer AM
听力损失（ARHL）是一种非常常见的感觉障碍，影响三分之一的老年人。在小鼠模型中建立老年性耳聋的解剖学、生理学和行为学标志物之间的联系可以提高对人类这种疾病的理解。我们测量ARHL的各种声音信号在安静和嘈杂的环境中使用操作性条件反射程序，并调查CBA/CaJ小鼠的外周结构的状态。老鼠在其生命的最后三分之一表现出最大程度的听力损失，在嘈杂的环境中比在安静的环境中具有更高的阈值。听性脑干反应阈值和波形形态的变化先于行为性听力损失发作。在老年小鼠中观察到毛细胞、听觉神经纤维的损失和血管纹变性的迹象。目前的工作强调了将年龄相关性听力损失的主要原因归因于任何特定类型的细胞变性的困难。揭示这些复杂的结构-功能关系对于建立成功的干预策略以恢复听力或预防老年性耳聋至关重要。
Age-related hearing loss (ARHL) is a very common sensory disability, affecting one in three older adults. Establishing a link between anatomical, physiological, and behavioral markers of presbycusis in a mouse model can improve the understanding of this disorder in humans. We measured ARHL for a variety of acoustic signals in quiet and noisy environments using an operant conditioning procedure, and investigated the status of peripheral structures in CBA/CaJ mice. Mice showed the greatest degree of hearing loss in the last third of their lifespan, with higher thresholds in noisy than in quiet conditions. Changes in auditory brainstem response thresholds and waveform morphology preceded behavioral hearing loss onset. Loss of hair cells, auditory nerve fibers, and signs of stria vascularis degeneration were observed in old mice. The present work underscores the difficulty in ascribing the primary cause of age-related hearing loss to any particular type of cellular degeneration. Revealing these complex structure-function relationships is critical for establishing successful intervention strategies to restore hearing or prevent presbycusis.
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