CBA/CaJ mouse ultrasonic vocalizations depend on prior social experience.
CBA/CaJ mouse ultrasonic vocalizations depend on prior social experience.
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DOI：
10.1371/journal.pone.0197774
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Dent ML
中科院分区：
文献类型：
--
作者：
Burke K;Screven LA;Dent ML
小鼠超声发声(USV)具有不同的频谱特征，研究人员使用这些特征将其解析为不同的类别。USV可能对交流很重要，但尚不清楚研究人员开发的类别是否与小鼠相关。相反，发声的数量、速率、峰值频率或带宽等其他属性可能是老鼠用来解释社交互动性质的重要线索。为了研究这一点，必须创建一份关于老鼠在不同社会背景下产生的紫外线的全面目录。40只成年雄性和雌性CBA/CAJ小鼠在隔离一小时或暴露于同性或异性小鼠后，被记录在隔离中5分钟。根据每个USV的频率组成，发声被分为九类。此外，根据带宽、持续时间、峰值频率、总数和发声比例对USV进行了量化。结果表明，小鼠在不同的社交场合发出不同的声音。小鼠在不同暴露条件下产生的USV数量、不同性别和条件下产生不同类别USV的比例概率以及不同条件下USV的特征存在显著差异。总而言之，实验室小鼠的USV的产生存在性别差异，先前的社会经验对发声的产生很重要。此外，这项研究提供了关键证据，证明雌性小鼠在异性互动中可能会发出发声，这一点很重要，因为这是小鼠交流研究中经常被忽视的变量。
Mouse ultrasonic vocalizations (USVs) have variable spectrotemporal features, which researchers use to parse them into different categories. USVs may be important for communication, but it is unclear whether the categories that researchers have developed are relevant to the mice. Instead, other properties such as the number, rate, peak frequency, or bandwidth of the vocalizations may be important cues that the mice are using to interpret the nature of the social interaction. To investigate this, a comprehensive catalog of the USVs that mice are producing across different social contexts must be created. Forty male and female adult CBA/CaJ mice were recorded in isolation for five minutes following either a one-hour period of isolation or an exposure to a same- or opposite-sex mouse. Vocalizations were separated into nine categories based on the frequency composition of each USV. Additionally, USVs were quantified based on the bandwidth, duration, peak frequency, total number, and proportion of vocalizations produced. Results indicate that mice differentially produce their vocalizations across social encounters. There were significant differences in the number of USVs that mice produce across exposure conditions, the proportional probability of producing the different categories of USVs across sex and conditions, and the features of the USVs across conditions. In sum, there are sex-specific differences in production of USVs by laboratory mice, and prior social experiences matter for vocalization production. Furthermore, this study provides critical evidence that female mice probably produce vocalizations in opposite-sex interactions, which is important because this is an often overlooked variable in mouse communication research.
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