Diffusion-prepared fast spin echo for artifact-free spinal cord imaging.
Diffusion-prepared fast spin echo for artifact-free spinal cord imaging.
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DOI：
10.1002/mrm.28751
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发表时间：
2021-08
影响因子：
3.3
通讯作者：
Budde MD
中科院分区：
文献类型：
--
作者：
Lee SY;Meyer BP;Kurpad SN;Budde MD
弥散MRI提供了独特的对比度，对于检测和检查急性神经损伤（包括脊髓损伤（SCI））后的病理生理学非常重要。啮齿动物脊髓的扩散加权成像（DWI）通常采用轴向回波平面成像读数（EPI）进行评价。然而，DWI容易出现运动伪影，而EPI容易出现磁化率伪影。在急性SCI的背景下，扩散过滤先前已被证明可以通过最小化水肿的混淆效应来改善损伤的检测。这项工作提出了一种扩散准备模块结合快速采集与弛豫增强（RARE）读出，以尽量减少伪影的矢状面成像。采用Sprague-Dawley大鼠颈挫伤模型，在9.4T下扫描。序列优化包括评价运动补偿编码（MCE）扩散梯度、门控策略和不同脊髓特异性扩散加权方案。弥散准备（DWprep）RARE获得了无磁敏感性伪影的高质量图像，需要使用二阶MCE和门控来减少运动伪影。从过滤扩散编码方案获得的平行扩散率与DTI的类似度量（25%）相比，病变与健康组织的对比度更高（52%）。这项工作证明了高质量的扩散矢状面成像在啮齿动物颈髓DWprep-RARE的可行性。该序列和结果有望改善急性SCI的损伤检测和评估。
Diffusion MRI provides unique contrast important for the detection and examination of pathophysiology after acute neurologic insults including spinal cord injury (SCI). Diffusion weighted imaging (DWI) of the rodent spinal cord has typically been evaluated with axial echo planar imaging readout (EPI). However, DWI is prone to motion artifacts, while EPI is prone to susceptibility artifacts. In the context of acute SCI, diffusion filtering has previously been shown to improve detection of injury by minimizing the confounding effects of edema. This work proposes a diffusion preparation module combined with a rapid acquisition with relaxation enhancement (RARE) readout to minimize artifacts for sagittal imaging. Sprague-Dawley rats with cervical contusion spinal cord injury were scanned at 9.4T. The sequence optimization included evaluation motion compensated encoding (MCE) diffusion gradients, gating strategy, and different spinal cord-specific diffusion weighting schemes. Diffusion prepared (DWprep) RARE achieved high-quality images free from susceptibility artifacts, with both second order MCE and gating necessary for reduction of motion artifacts. Parallel diffusivity obtained from the filtered diffusion encoding scheme had greater lesion-to-healthy tissue contrast (52%) compared to the similar metric from DTI (25%). This work demonstrated the feasibility of high-quality diffusion sagittal imaging in the rodent cervical cord with DWprep-RARE. The sequence and results are expected to improve injury detection and evaluation in acute SCI.
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DOI：
10.1080/13623699.2021.1955759
发表时间：
2021-09-01
期刊：
Medicine, conflict, and survival
影响因子：
--
作者：
Lee, Soomin;Nganji, Julius T;Cockburn, Lynn
通讯作者：
Cockburn, Lynn
影响因子：
3.3
作者：
Kharbanda, Hardave S.;Alsop, David C.;Hackney, David B.
通讯作者：
Hackney, David B.
影响因子：
3.3
作者：
NORRIS, DG;BORNERT, P;LEIBFRITZ, D
通讯作者：
LEIBFRITZ, D
影响因子：
3.3
作者：
Meakin, James A.;Jezzard, Peter
通讯作者：
Jezzard, Peter
影响因子：
3.3
作者：
Nguyen, Christopher;Fan, Zhaoyang;Li, Debiao
通讯作者：
Li, Debiao