Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?
Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?
复制标题
胰岛素抵抗和高血压之间的联系：进化生物学的证据是什么？
DOI：
10.1186/1758-5996-6-12
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发表时间：
2014-01-31
影响因子：
4.8
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Zhou MS;Wang A;Yu H
胰岛素抵抗和高血压被认为是典型的“文明疾病”，在现代环境中表现为丰富的食物和久坐的生活。人类对胰岛素抵抗和高血压的倾向是我们进化史的产物，至少部分是这样。适应以低钠、低热量食物供应和对伤害反应的身体压力为特征的古代生活方式，促使我们进化形成并保存了一种节俭的基因型，这种基因型最受节能和钠节约的欢迎。随着我们文明的进化，久坐不动的生活方式和富含钠和能量的饮食，节俭的基因型不再具有优势，并且可能不适应疾病表型，如高血压、肥胖和胰岛素抵抗综合征。本文综述了人类进化和现代环境对高血压和胰岛素抵抗的影响。
Insulin resistance and hypertension are considered as prototypical “diseases of civilization” that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancient lifestyle characterized by a low sodium, low-calorie food supply and physical stress to injury response has driven our evolution to shape and preserve a thrifty genotype, which is favorite with energy-saving and sodium conservation. As our civilization evolved, a sedentary lifestyle and sodium- and energy-rich diet, the thrifty genotype is no longer advantageous, and may be maladaptive to disease phenotype, such as hypertension, obesity and insulin resistance syndrome. This article reviews human evolution and the impact of the modern environment on hypertension and insulin resistance.
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