A new estimation approach for combining epidemiological data from multiple sources.

A new estimation approach for combining epidemiological data from multiple sources.
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DOI:
10.1080/01621459.2013.870904
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发表时间:
2014-01-01
影响因子:
3.7
通讯作者:
Guan Y
Guan Y
中科院分区:
数学1区
文献类型:
--
作者:
Huang H;Ma X;Waagepetersen R;Holford TR;Wang R;Risch H;Mueller L;Guan Y

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我们提出了一种新的两步程序,结合联合收割机流行病学数据从不同的来源,目的是量化的风险因素影响的概率,一个人发展某些疾病,如癌症。在第一步中,我们推导出所有可能的无偏估计函数的基础上,一组情况下,一组控制的每一次。第二步,将这些估计函数进行联合收割机有效的组合,以充分利用数据中所包含的信息。我们的方法是计算简单和灵活的。我们通过模拟来说明它的功效,并将其应用于调查胰腺癌的风险,这些数据来自康涅狄格州肿瘤登记处,一项基于人群的病例对照研究,以及行为风险因素监测系统,这是一个基于州的健康调查系统。
We propose a novel two-step procedure to combine epidemiological data obtained from diverse sources with the aim to quantify risk factors affecting the probability that an individual develops certain disease such as cancer. In the first step we derive all possible unbiased estimating functions based on a group of cases and a group of controls each time. In the second step, we combine these estimating functions efficiently in order to make full use of the information contained in data. Our approach is computationally simple and flexible. We illustrate its efficacy through simulation and apply it to investigate pancreatic cancer risks based on data obtained from the Connecticut Tumor Registry, a population-based case-control study, and the Behavioral Risk Factor Surveillance System which is a state-based system of health surveys.
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