Crossover patterning in plants.
Crossover patterning in plants.
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DOI：
10.1007/s00497-022-00445-4
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发表时间：
2023-03
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
染色质状态和前交换蛋白HEI10在重组中间体的动态加载形成植物中的减数分裂染色体图案。减数分裂是有性生殖的基础，其基本进程在真核生物界中是保守的。减数分裂的一个关键特征是形成交叉，这导致母本和父本染色体片段的相互交换。这种交换产生了具有新的等位基因组合的染色体，提高了自然选择和人工选择的效率。在中期I，杂交也在同源染色体之间形成物理联系，这对于准确的染色体分离和育性至关重要。沿着沿着染色体长度的交叉模式是一个高度调节的过程，我们目前对其调节的理解形成了本文的重点。在全球范围内，植物中的交叉模式在很大程度上是由经典观察到的交叉干扰，交叉稳态和强制性交叉现象控制的，这些现象调节交叉的总数和它们的相对间隔。这些现象背后的分子演员长期以来一直不清楚，但最近的植物研究表明HEI10和ZYP1是它们协调的关键角色。除了这些广泛的力量，最近的大量研究强调了基因组和表观基因组特征如何在染色体和局部尺度上形成交叉，揭示了交叉主要位于与基因启动子和终止子相关的开放染色质中，具有低核小体占有率。
Chromatin state, and dynamic loading of pro-crossover protein HEI10 at recombination intermediates shape meiotic chromosome patterning in plants. Meiosis is the basis of sexual reproduction, and its basic progression is conserved across eukaryote kingdoms. A key feature of meiosis is the formation of crossovers which result in the reciprocal exchange of segments of maternal and paternal chromosomes. This exchange generates chromosomes with new combinations of alleles, increasing the efficiency of both natural and artificial selection. Crossovers also form a physical link between homologous chromosomes at metaphase I which is critical for accurate chromosome segregation and fertility. The patterning of crossovers along the length of chromosomes is a highly regulated process, and our current understanding of its regulation forms the focus of this review. At the global scale, crossover patterning in plants is largely governed by the classically observed phenomena of crossover interference, crossover homeostasis and the obligatory crossover which regulate the total number of crossovers and their relative spacing. The molecular actors behind these phenomena have long remained obscure, but recent studies in plants implicate HEI10 and ZYP1 as key players in their coordination. In addition to these broad forces, a wealth of recent studies has highlighted how genomic and epigenomic features shape crossover formation at both chromosomal and local scales, revealing that crossovers are primarily located in open chromatin associated with gene promoters and terminators with low nucleosome occupancy.
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影响因子：
30.8
作者：
Choi, Kyuha;Zhao, Xiaohui;Kelly, Krystyna A.;Venn, Oliver;Higgins, James D.;Yelina, Nataliya E.;Hardcastle, Thomas J.;Ziolkowski, Piotr A.;Copenhaver, Gregory P.;Franklin, F. Chris H.;McVean, Gil;Henderson, Ian R.
通讯作者：
Henderson, Ian R.
DOI：
10.15252/embj.2020104858
发表时间：
2020-11-02
期刊：
The EMBO journal
影响因子：
--
作者：
Blackwell AR;Dluzewska J;Szymanska-Lejman M;Desjardins S;Tock AJ;Kbiri N;Lambing C;Lawrence EJ;Bieluszewski T;Rowan B;Higgins JD;Ziolkowski PA;Henderson IR
通讯作者：
Henderson IR
影响因子：
12.3
作者：
Bauer E;Falque M;Walter H;Bauland C;Camisan C;Campo L;Meyer N;Ranc N;Rincent R;Schipprack W;Altmann T;Flament P;Melchinger AE;Menz M;Moreno-González J;Ouzunova M;Revilla P;Charcosset A;Martin OC;Schön CC
通讯作者：
Schön CC
DOI：
10.1073/pnas.1416622112
发表时间：
2015-02-17
影响因子：
11.1
作者：
Arbeithuber, Barbara;Betancourt, Andrea J.;Tiemann-Boege, Irene
通讯作者：
Tiemann-Boege, Irene
影响因子：
56.9
作者：
Borde, V;Goldman, ASH;Lichten, M
通讯作者：
Lichten, M