Adaptive immunity, chronic inflammation and the clock.
Adaptive immunity, chronic inflammation and the clock.
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自适应免疫，慢性炎症和时钟。
DOI：
10.1007/s00281-022-00919-7
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发表时间：
2022-03
影响因子：
9
通讯作者：
Gibbs JE
中科院分区：
文献类型：
--
作者：
Gray KJ;Gibbs JE
免疫系统的适应性臂有助于识别特定的外来病原体，并通过T和B淋巴细胞的作用，诱导针对病原体的微调反应，发展免疫记忆。适应性免疫系统的功能在动态平衡过程(如淋巴细胞的运输和T淋巴细胞亚群的发展)和对挑战的反应中都表现出每天24小时的变化。在这里，我们讨论了生物钟如何影响适应性免疫系统的功能，考虑到细胞内在的时钟机制和细胞外部节奏信号的作用。适应性免疫系统不适当或被误导的行为可能会导致自身免疫性疾病的发展，如类风湿性关节炎、溃疡性结肠炎和多发性硬化症。越来越多的证据表明，生物钟的紊乱对这些慢性炎症性疾病的发展和进展有负面影响，我们检查了目前对这些炎症条件下生物钟-免疫相互作用的理解。更好地了解适应性免疫的昼夜节律控制将有助于进一步了解推动疾病状态每日变化的机制，并推动慢性炎症性疾病的诊断和治疗的改进。
The adaptive arm of the immune system facilitates recognition of specific foreign pathogens and, via the action of T and B lymphocytes, induces a fine-tuned response to target the pathogen and develop immunological memory. The functionality of the adaptive immune system exhibits daily 24-h variation both in homeostatic processes (such as lymphocyte trafficking and development of T lymphocyte subsets) and in responses to challenge. Here, we discuss how the circadian clock exerts influence over the function of the adaptive immune system, considering the roles of cell intrinsic clockwork machinery and cell extrinsic rhythmic signals. Inappropriate or misguided actions of the adaptive immune system can lead to development of autoimmune diseases such as rheumatoid arthritis, ulcerative colitis and multiple sclerosis. Growing evidence indicates that disturbance of the circadian clock has negative impact on development and progression of these chronic inflammatory diseases and we examine current understanding of clock-immune interactions in the setting of these inflammatory conditions. A greater appreciation of circadian control of adaptive immunity will facilitate further understanding of mechanisms driving daily variation in disease states and drive improvements in the diagnosis and treatment of chronic inflammatory diseases.
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淋巴细胞昼夜节律的时钟控制淋巴结运输和适应性免疫反应。
影响因子：
32.4
作者：
Druzd D;Matveeva O;Ince L;Harrison U;He W;Schmal C;Herzel H;Tsang AH;Kawakami N;Leliavski A;Uhl O;Yao L;Sander LE;Chen CS;Kraus K;de Juan A;Hergenhan SM;Ehlers M;Koletzko B;Haas R;Solbach W;Oster H;Scheiermann C
通讯作者：
Scheiermann C
影响因子：
7.3
作者：
Di Rosa F;Gebhardt T
通讯作者：
Gebhardt T
影响因子：
3.2
作者：
Chen HC;Chen YC;Wang TN;Fang WF;Chang YC;Chen YM;Chen IY;Lin MC;Yang MY
通讯作者：
Yang MY
影响因子：
14.9
作者：
Cheon S;Park N;Cho S;Kim K
通讯作者：
Kim K
影响因子：
3.4
作者：
Buijs, RM;Wortel, J;Kalsbeek, A
通讯作者：
Kalsbeek, A