Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
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有和没有急性后症状的新冠肺炎康复者的长期SARS-CoV-2特异性免疫和炎症反应。
DOI：
10.1016/j.celrep.2021.109518
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发表时间：
2021-08-10
期刊：
影响因子：
8.8
通讯作者：
Henrich TJ
中科院分区：
文献类型：
--
作者：
Peluso MJ;Deitchman AN;Torres L;Iyer NS;Munter SE;Nixon CC;Donatelli J;Thanh C;Takahashi S;Hakim J;Turcios K;Janson O;Hoh R;Tai V;Hernandez Y;Fehrman EA;Spinelli MA;Gandhi M;Trinh L;Wrin T;Petropoulos CJ;Aweeka FT;Rodriguez-Barraquer I;Kelly JD;Martin JN;Deeks SG;Greenhouse B;Rutishauser RL;Henrich TJ
我们纵向描述了 70 名经 PCR 确诊的 SARS-CoV-2 感染者的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 特异性 T 细胞反应、可溶性炎症标志物以及抗体水平和中和能力。参与者代表了一系列疾病和康复情况，包括一些唾液中持续病毒脱落的人，以及许多经历 SARS-CoV-2 感染 (PASC) 急性后遗症的人。 T 细胞反应可保持稳定长达 9 个月。虽然早期 CD4+ T 细胞免疫反应的强度与初始感染的严重程度相关，但先前存在的肺部疾病与较高的长期 SARS-CoV-2 特异性 CD8+ T 细胞反应独立相关。在 2019 年冠状病毒病 (COVID-19) 症状出现 4 个月后患有 PASC 的参与者中，我们观察到响应核衣壳 (N) 肽库刺激而表达脱颗粒标志物 CD107a 的 CD8+ T 细胞频率较低，并且产生 N 特异性干扰素 γ 的 CD8+ T 细胞频率下降更快。中和抗体水平与 SARS-CoV-2 特异性 CD4+ T 细胞反应密切相关。自然感染 COVID-19 后，CD4+ 和 CD8+ T 细胞反应在 8 个月内保持稳定。患有 PASC 的个体表现出表达 CD107a（脱颗粒标志物）的 CD8+ T 细胞频率较低，并且产生 N 特异性干扰素 γ 的 CD8+ T 细胞频率下降更快。
We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses, soluble markers of inflammation, and antibody levels and neutralization capacity longitudinally in 70 individuals with PCR-confirmed SARS-CoV-2 infection. Participants represent a spectrum of illness and recovery, including some with persistent viral shedding in saliva and many experiencing post-acute sequelae of SARS-CoV-2 infection (PASC). T cell responses remain stable for up to 9 months. Whereas the magnitude of early CD4+ T cell immune responses correlates with severity of initial infection, pre-existing lung disease is independently associated with higher long-term SARS-CoV-2-specific CD8+ T cell responses. Among participants with PASC 4 months following coronavirus disease 2019 (COVID-19) symptom onset, we observe a lower frequency of CD8+ T cells expressing CD107a, a marker of degranulation, in response to Nucleocapsid (N) peptide pool stimulation, and a more rapid decline in the frequency of N-specific interferon-γ-producing CD8+ T cells. Neutralizing antibody levels strongly correlate with SARS-CoV-2-specific CD4+ T cell responses. CD4+ and CD8+ T cell responses following natural infection with COVID-19 are stable over 8 months. Individuals with PASC demonstrate a lower frequency of CD8+ T cells expressing CD107a, a marker of degranulation, and a more rapid decline in the frequency of N-specific interferon-γ-producing CD8+ T cells.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
5.4
作者：
Avadhanula, V;Rodriguez, CA;Adderson, EE
通讯作者：
Adderson, EE
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
158.5
作者：
Gudbjartsson, Daniel F.;Norddahl, Gudmundur L.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
64.5
作者：
Moderbacher, Carolyn Rydyznski;Ramirez, Sydney, I;Crotty, Shane
通讯作者：
Crotty, Shane