Adaptive optics and the eye (super resolution OCT).
Adaptive optics and the eye (super resolution OCT).
复制标题
自适应光学和眼睛（超级分辨率OCT）。
作者：
Miller, D. T.;Kocaoglu, O. P.;Wang, Q.;Lee, S.
关键词：
自适应光学（AO）和光学相干层析成像（OCT）的结合在8年前首次被报道，自那时以来已经取得了巨大的技术进步。将AO添加到OCT的技术优势（增加横向分辨率，减小斑点和增强灵敏度）提高了OCT的成像能力，使其非常适合视网膜中的三维（3D）细胞成像。如今，AO-OCT系统提供超高3D分辨率（3 × 3 × 3µm3）和超高速度（比商用OCT快一个数量级）。AO-OCT系统已被用于捕获视网膜结构的体积图像，以前只能在组织学上看到，并被用于研究临床条件。在这里，我们展示了可以用AO-OCT可视化的细胞结构的代表性例子。我们概述了我们实验室的三项研究，这些研究使用超高分辨率AO-OCT来测量视网膜神经纤维层中单个束的横截面；决定中央凹无血管区终末边缘的中央凹毛细血管的直径；单个视锥光感受器外节的间距和长度与中央凹中心接近0.5°。
The combination of adaptive optics (AO) and optical coherence tomography (OCT) was first reported 8 years ago and has undergone tremendous technological advances since then. The technical benefits of adding AO to OCT (increased lateral resolution, smaller speckle, and enhanced sensitivity) increase the imaging capability of OCT in ways that make it well suited for three-dimensional (3D) cellular imaging in the retina. Today, AO–OCT systems provide ultrahigh 3D resolution (3 × 3 × 3 µm3) and ultrahigh speed (up to an order of magnitude faster than commercial OCT). AO–OCT systems have been used to capture volume images of retinal structures, previously only visible with histology, and are being used for studying clinical conditions. Here, we present representative examples of cellular structures that can be visualized with AO–OCT. We overview three studies from our laboratory that used ultrahigh-resolution AO–OCT to measure the cross-sectional profiles of individual bundles in the retinal nerve fiber layer; the diameters of foveal capillaries that define the terminal rim of the foveal avascular zone; and the spacing and length of individual cone photoreceptor outer segments as close as 0.5° from the fovea center.
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