Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A.
Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A.
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肺表面活性物质与脓毒症成年小鼠的炎症：表面活性剂蛋白 A 的作用。
DOI：
10.1152/japplphysiol.00628.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Lewis,JamesF
中科院分区：
文献类型：
--
作者：
Malloy,JaretL;Veldhuizen,RuudAW;McCormack,FrancisX;Korfhagen,ThomasR;Whitsett,JefferyA;Lewis,JamesF
Surfactant alterations, alveolar cytokine changes, and the role of surfactant protein (SP)-A in septic mice were investigated. Sepsis was induced via cecal ligation and perforation (CLP). Septic and sham mice were euthanized at 0, 3, 6, 9, 12, 15, and 18 h after surgery. Mice deficient in SP-A and mice that overexpressed SP-A were euthanized 18 h after surgery. In wild-type, sham-operated mice, surfactant pool sizes were similar at all time points, whereas in the CLP groups there was a significant decrease in small-aggregate surfactant pool sizes beginning 6 h after CLP. Interleukin-6 concentrations in bronchoalveolar lavage fluid from septic animals increased from 6 to 18 h after surgery. Identical surfactant alterations and concentrations of cytokines were observed in septic mice that were SP-A deficient or that overexpressed SP-A. In conclusion, alterations of pulmonary surfactant and alveolar cytokines occur simultaneously, 6 h after a systemic insult. In addition, we did not detect a role for SP-A in regulating surfactant phospholipid pool sizes or pulmonary inflammation in septic mice.
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DOI：
10.1165/ajrcmb.21.3.3676
发表时间：
1999-09-01
影响因子：
6.4
作者：
Elhalwagi, BM;Zhang, M;McCormack, FX
通讯作者：
McCormack, FX
DOI：
10.1073/pnas.93.18.9594
发表时间：
1996-09-03
影响因子：
11.1
作者：
Korfhagen, TR;Bruno, MD;Whitsett, JA
通讯作者：
Whitsett, JA
DOI：
10.1152/ajplung.2000.278.4.l840
发表时间：
2000-04-01
影响因子：
4.9
作者：
Borron, P;McIntosh, JC;Wright, JR
通讯作者：
Wright, JR
表面活性剂治疗改变兔肺内源性表面活性剂代谢。
DOI：
10.1152/jappl.1990.68.4.1590
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Oetomo,SB;Lewis,J;Ikegami,M;Jobe,AH
通讯作者：
Jobe,AH
肿瘤坏死因子-α 抑制表面活性剂蛋白 C 基因转录 (*)
影响因子：
4.8
作者：
C. Bachurski;G. Pryhuber;S. Glasser;S. Kelly;J. Whitsett
通讯作者：
J. Whitsett