Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study.
Evaluating cortical responses to speech in children: A functional near-infrared spectroscopy (fNIRS) study.
复制标题
评估儿童语言皮层反应：一项功能性近红外光谱（fNIRS）研究。
DOI：
10.1016/j.heares.2020.108155
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发表时间：
2021-03-01
期刊：
影响因子：
2.8
通讯作者：
Hartley DEH
中科院分区：
文献类型：
--
作者：
Lawrence RJ;Wiggins IM;Hodgson JC;Hartley DEH
fNIRS具有提供言语理解的客观测量的潜力。左上上级时间激活与语音清晰度单调增长。fNIRS反应也随其他皮层区域的语音清晰度而变化。右后中颞区表现出相对失活。在更困难的收听条件下，去激活的幅度更大。言语加工的功能性神经成像具有研究和临床潜力。这项工作正在促进对语音处理中涉及的复杂神经机制的不断增长的理解。言语理解的神经相关性也具有潜在的临床价值，特别是对于婴儿和儿童，他们的行为评估可能不可靠。这些措施不仅有益于听力正常的儿童，也有益于有听力障碍的儿童。在目前的研究中，我们研究了听力正常的儿童听众的语音清晰度的皮质相关性。使用功能性近红外光谱（fNIRS）测量皮质反应，fNIRS是一种非侵入性神经成像技术，与听力设备（包括人工耳蜗）完全兼容。在19名听力正常的儿童（6 - 13岁）中，我们测量了双侧颞叶和额叶皮层的活动，同时参与者听取了针对四个级别的语音清晰度的清晰和噪声声码句子。大脑左半球的上级颞叶皮层和额叶下皮层的激活普遍强于右半球。左上级颞叶皮层的激活随着语言清晰度的增加而单调增长。在同一区域，我们发现了正确感知试验与不正确感知试验的更大激活趋势，这表明对语音清晰度本身可能具有敏感性，超出了对刺激条件下声学特性变化的敏感性。在上级颞叶皮层之外，我们发现了其他区域，其中fNIRS反应随语音清晰度而变化。例如，覆盖右半球后中颞区的通道在句子处理过程中表现出相对失活（与无声基线条件相比），在更困难的听力条件下，失活的幅度更大。这一发现可能代表的默认模式网络的组件在横向颞区的敏感性，因此努力听正常听力儿科听众。我们的研究结果表明，fNIRS有可能提供一个客观的标记正常听力儿童的语音清晰度。如果发现这些结果适用于经历语言延迟的个体或通过听力设备（如人工耳蜗植入物）收听的个体，fNIRS可能构成临床上有用的言语理解测量的基础。
fNIRS has the potential to provide an objective measure of speech understanding. Left superior temporal activation grows monotonically with speech intelligibility. fNIRS responses also vary with speech intelligibility in other cortical regions. Right posterior middle temporal regions exhibit relative deactivation. The amplitude of deactivation is greater in more difficult listening conditions. Functional neuroimaging of speech processing has both research and clinical potential. This work is facilitating an ever-increasing understanding of the complex neural mechanisms involved in the processing of speech. Neural correlates of speech understanding also have potential clinical value, especially for infants and children, in whom behavioural assessments can be unreliable. Such measures would not only benefit normally hearing children experiencing speech and language delay, but also hearing impaired children with and without hearing devices. In the current study, we examined cortical correlates of speech intelligibility in normally hearing paediatric listeners. Cortical responses were measured using functional near-infrared spectroscopy (fNIRS), a non-invasive neuroimaging technique that is fully compatible with hearing devices, including cochlear implants. In nineteen normally hearing children (aged 6 – 13 years) we measured activity in temporal and frontal cortex bilaterally whilst participants listened to both clear- and noise-vocoded sentences targeting four levels of speech intelligibility. Cortical activation in superior temporal and inferior frontal cortex was generally stronger in the left hemisphere than in the right. Activation in left superior temporal cortex grew monotonically with increasing speech intelligibility. In the same region, we identified a trend towards greater activation on correctly vs. incorrectly perceived trials, suggesting a possible sensitivity to speech intelligibility per se, beyond sensitivity to changing acoustic properties across stimulation conditions. Outside superior temporal cortex, we identified other regions in which fNIRS responses varied with speech intelligibility. For example, channels overlying posterior middle temporal regions in the right hemisphere exhibited relative deactivation during sentence processing (compared to a silent baseline condition), with the amplitude of that deactivation being greater in more difficult listening conditions. This finding may represent sensitivity to components of the default mode network in lateral temporal regions, and hence effortful listening in normally hearing paediatric listeners. Our results indicate that fNIRS has the potential to provide an objective marker of speech intelligibility in normally hearing children. Should these results be found to apply to individuals experiencing language delay or to those listening through a hearing device, such as a cochlear implant, fNIRS may form the basis of a clinically useful measure of speech understanding.
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影响因子：
5.7
作者：
Buchel, C;Holmes, AP;Friston, KJ
通讯作者：
Friston, KJ
影响因子：
1.9
作者：
Custo, Anna;Wells, William M., III;Boas, David A.
通讯作者：
Boas, David A.
影响因子：
3.7
作者：
Besseling RM;Jansen JF;Overvliet GM;van der Kruijs SJ;Ebus SC;de Louw A;Hofman PA;Vles JS;Aldenkamp AP;Backes WH
通讯作者：
Backes WH
影响因子：
5.2
作者：
Andrews-Hanna JR;Smallwood J;Spreng RN
通讯作者：
Spreng RN
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y