Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy.
Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy.
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DOI：
10.1371/journal.pone.0083568
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Backes WH
中科院分区：
文献类型：
--
作者：
Besseling RM;Jansen JF;Overvliet GM;van der Kruijs SJ;Ebus SC;de Louw A;Hofman PA;Vles JS;Aldenkamp AP;Backes WH
罗兰癫痫（RE）是一种具有中央颞（罗兰）棘波的儿童癫痫，与语言障碍的关系越来越密切。在这项研究中，我们测试了一个白色物质（连接）相关，采用扩散加权MRI和语言测试。23名RE儿童和23名匹配的对照组（年龄：8-14岁）在3 T下接受了结构（T1加权）和弥散加权MRI（B = 1200 s/mm 2，66个梯度方向），以及神经心理语言测试。 结合纤维束成像和皮质分割来自T1扫描，罗兰道重建（前和后中央回），并道分数各向异性（FA）值进行了比较患者和对照组之间。测试了异常声道与语言表现的相关性。与对照组相比，发现患者的FA减少，主要在左半球;最显著的影响涉及左额下回（p = 0.005）和缘上回（p = 0.004）。 在患者组中，下束FA值与较低的语言表现相关，其中包括左中央后回和额下回之间的连接（p = 0.043，R = 0.43）。 在RE中，涉及癫痫样活动起源的罗兰区的几个连接的结构连接性降低。这些异常的神经束大部分涉及左半球（通常是语言中介），特别是额下回（布罗卡区）和缘上回（韦尼克区）的盖部。对于前者，在患者中发现了下道FA的语言表现降低。这些发现提供了第一个微观结构的白色物质与RE语言障碍。
Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. Twenty-three children with RE and 23 matched controls (age: 8–14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm2, 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca’s area) and the supramarginal gyrus (Wernicke’s area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.
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影响因子：
3.7
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
影响因子：
4.2
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
影响因子：
5.6
作者：
Datta, Alexandre N.;Oser, Nadine;Penner, Iris-Katharina
通讯作者：
Penner, Iris-Katharina
影响因子：
11.2
作者：
Catani, M;Jones, DK;Ffytche, DH
通讯作者：
Ffytche, DH
影响因子：
3.4
作者：
Fonseca Vde C;Yasuda CL;Tedeschi GG;Betting LE;Cendes F
通讯作者：
Cendes F