In vitro results of flexible light-emitting antimicrobial bandage designed for prevention of surgical site infections
In vitro results of flexible light-emitting antimicrobial bandage designed for prevention of surgical site infections
复制标题
用于预防手术部位感染的柔性发光抗菌绷带的体外结果
DOI：
10.1117/12.2290743
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Cirillo, Jeffrey D.
中科院分区：
文献类型：
--
作者：
Greenberg, Mitchell;Maitland, Kristen C.;Smith, Robert;Glowczwski, Alan;Lovelady, April;Galbadage, Thushara;Sule, Preeti;Sharan, Riti;Cirillo, Jeffrey D.
手术部位感染（SSI）是发病率和死亡率的主要原因，也是医疗保健系统和医院的重大支出。这些感染中的大多数是可以预防的;然而，细菌耐药性增加、生物膜持久性和人为错误导致了这些医疗保健相关感染的发生。我们提出了一种灵活的抗菌蓝光发射绷带设计用于术后切口和伤口。光子装置被设计为抑制皮肤上存在的细菌并防止细菌在该部位定植，从而减少SSI的发生。这种抗菌发光绷带利用蓝光的成熟能力来杀灭各种临床病原体，而不管它们对抗生素的耐药性如何，杀灭细菌而不伤害哺乳动物细胞，改善伤口愈合，并杀灭生物膜中的细菌。抗菌绷带由一个2“x2”的薄硅胶片组成，其中77个LED阵列嵌入多层材料中，用于热管理。中心波长为405 nm的LED阵列被设计成一种可穿戴设备，与标准的医院感染预防协议集成。该装置的特征在于辐照度为44.5 mW/cm 2。将耐甲氧西林金黄色葡萄球菌接种于培养皿中，以评价细菌的体外灭活。从2.16 x 107菌落形成单位（CFU）/mL的浓度开始，45%的细菌在15分钟内被灭活，65%在30分钟内被灭活，99%在60分钟内被灭活，7个对数减少和完全灭菌在120分钟内实现。
Surgical site infections (SSIs) are a leading cause of morbidity and mortality and a significant expense to the healthcare system and hospitals. The majority of these infections are preventable; however, increasing bacterial resistance, biofilm persistence, and human error contribute to the occurrence of these healthcare-associated infections. We present a flexible antimicrobial blue-light emitting bandage designed for use on postoperative incisions and wounds. The photonic device is designed to inactivate bacteria present on the skin and prevent bacterial colonization of the site, thus reducing the occurrence of SSIs. This antimicrobial light emitting bandage uses blue light’s proven abilities to inactivate a wide range of clinical pathogens regardless of their resistance to antibiotics, inactivate bacteria without harming mammalian cells, improve wound healing, and inactivate bacteria in biofilms. The antimicrobial bandage consists of a thin 2”x2” silicone sheet with an array of 77 LEDs embedded in multiple layers of the material for thermal management. The 405 nm center wavelength LED array is designed to be a wearable device that integrates with standard hospital infection prevention protocols. The device was characterized for irradiance of 44.5 mW/cm2. Methicillin-resistant Staphylococcusaureusseeded in a petri dish was used to evaluate bacterial inactivation in vitro. Starting with a concentration of 2.16 x 107colony forming units (CFU)/mL, 45% of the bacteria was inactivated within 15 minutes, 65% had been inactivated by 30 minutes, 99% was inactivated by 60 minutes, and a 7 log reduction and complete sterilization was achieved within 120 minutes.
DOI：
10.1152/ajplung.2000.279.6.l1005
发表时间：
2000-12
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
V. Thannickal;B. Fanburg
通讯作者：
V. Thannickal;B. Fanburg
影响因子：
--
作者：
Dai, Tianhong;Gupta, Asheesh;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
24.3
作者：
Dai, Tianhong;Gupta, Asheesh;Murray, Clinton K.;Vrahas, Mark S.;Tegos, George P.;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.