Endocrine Therapy for the Functional Recovery of Spinal Cord Injury.
Endocrine Therapy for the Functional Recovery of Spinal Cord Injury.
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DOI：
10.3389/fnins.2020.590570
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发表时间：
2020
影响因子：
4.3
通讯作者：
Wu AM
中科院分区：
文献类型：
--
作者：
Wang H;Zhou WX;Huang JF;Zheng XQ;Tian HJ;Wang B;Fu WL;Wu AM
脊髓损伤（SCI）是导致身体残疾的主要原因，并导致患者对其生活质量的不满。SCI患者通常表现出严重的临床症状，包括损伤水平以下的感觉和运动功能障碍、截瘫、四肢瘫痪和尿潴留，这可能加重巨大的医疗和社会负担。脊髓损伤的主要病理变化是炎症反应，导致神经元脱髓鞘、轴突变性、凋亡和坏死。传统的医学治疗主要集中在运动功能的恢复和并发症的预防。迄今为止，人们对脊髓损伤的细胞和分子机制进行了大量的研究，并提出了许多有效的治疗方法，但由于脊髓损伤后发病机制复杂，预后差，临床应用仍然受到限制。内分泌激素是由内分泌器官合成的一类分子，参与多种生理活动的调节，其对多种疾病的保护作用已被广泛讨论。此外，许多研究发现，内分泌激素可以促进中枢神经系统疾病患者的神经再生和功能恢复。因此，研究内分泌激素作为SCI治疗的临床应用是必要的。在这篇综述中，我们描述了几种内分泌激素在SCI中的神经保护作用;内分泌激素的管理减少细胞死亡，促进SCI后的功能修复。我们还提出了SCI的新疗法。
Spinal cord injury (SCI) is a major cause of physical disability and leads to patient dissatisfaction with their quality of life. Patients with SCI usually exhibit severe clinical symptoms, including sensory and motor dysfunction below the injured levels, paraplegia, quadriplegia and urinary retention, which can exacerbate the substantial medical and social burdens. The major pathological change observed in SCI is inflammatory reaction, which induces demyelination, axonal degeneration, and the apoptosis and necrosis of neurons. Traditional medical treatments are mainly focused on the recovery of motor function and prevention of complications. To date, numerous studies have been conducted to explore the cellular and molecular mechanism of SCI and have proposed lots of effective treatments, but the clinical applications are still limited due to the complex pathogenesis and poor prognosis after SCI. Endocrine hormones are kinds of molecules that are synthesized by specialized endocrine organs and can participate in the regulation of multiple physiological activities, and their protective effects on several disorders have been widely discussed. In addition, many studies have identified that endocrine hormones can promote nerve regeneration and functional recovery in individuals with central nervous system diseases. Therefore, studies investigating the clinical applications of endocrine hormones as treatments for SCI are necessary. In this review, we described the neuroprotective roles of several endocrine hormones in SCI; endocrine hormone administration reduces cell death and promotes functional repair after SCI. We also proposed novel therapies for SCI.
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DOI：
10.1016/j.mcn.2012.03.007
发表时间：
2012-05
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Dugas JC;Ibrahim A;Barres BA
通讯作者：
Barres BA
影响因子：
2.5
作者：
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通讯作者：
Sengelaub, Dale R.
DOI：
10.1038/nrd2792
发表时间：
2009-03
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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