mir-17-92, a cluster of miRNAs in the midst of the cancer network.
mir-17-92, a cluster of miRNAs in the midst of the cancer network.
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DOI：
10.1016/j.biocel.2010.03.004
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发表时间：
2010-08
影响因子：
4
通讯作者：
He, Lin
中科院分区：
文献类型：
--
作者：
Olive, Virginie;Jiang, Iris;He, Lin
MicroRNA (miRNA) 是一类丰富的小非编码 RNA (ncRNA)，其功能是在转录后水平调节基因表达。尽管它们的功能最初是在正常发育过程中描述的，但 miRNA 已成为致癌和肿瘤抑制网络的组成部分，调节肿瘤形成过程中几乎所有改变的细胞过程。特别是 mir-17-92，一种 miRNA 多顺反子，也称为 oncomir-1，是最有效的致癌 miRNA 之一。在几种人类 B 细胞淋巴瘤中都发现了 mir-17-92 的基因组扩增和表达升高，并且其强制表达在多种小鼠肿瘤模型中表现出强烈的致瘤活性。 mir-17-92 在正常发育和恶性转化过程中发挥多效性功能，因为它可以促进增殖、抑制分化、增加血管生成和维持细胞存活。与大多数蛋白质编码基因不同，mir-17-92 是一个多顺反子 miRNA 簇，包含多个 miRNA 组件，每个组件都有可能调节数百个目标 mRNA。 mir-17-92 的这种独特的基因结构可能是其以细胞类型和背景依赖性方式实现多效性功能的分子基础。在这里，我们回顾了有关 mir-17-92 功能研究的最新文献，并强调了其对癌基因网络的潜在影响。这些关于 mir-17-92 的发现表明 miRNA 与蛋白质编码基因一起是调节肿瘤发展和肿瘤维持的分子途径的整合组成部分。
MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs (ncRNAs) that function to regulate gene expression at the post-transcriptional level. Although their functions were originally described during normal development, miRNAs have emerged as integral components of the oncogenic and tumor suppressor network, regulating nearly all cellular processes altered during tumor formation. In particular, mir-17-92, a miRNA polycistron also known as oncomir-1, is among the most potent oncogenic miRNAs. Genomic amplification and elevated expression of mir-17-92 were both found in several human B-cell lymphomas, and its enforced expression exhibits strong tumorigenic activity in multiple mouse tumor models. mir-17-92 carries out pleiotropic functions during both normal development and malignant transformation, as it acts to promote proliferation, inhibit differentiation, increase angiogenesis and sustain cell survival. Unlike most protein coding genes, mir-17-92 is a polycistronic miRNA cluster that contains multiple miRNA components, each of which has a potential to regulate hundreds of target mRNAs. This unique gene structure of mir-17-92 may underlie the molecular basis for its pleiotropic functions in a cell type and context dependent manner. Here we review the recent literature on the functional studies of mir-17-92, and highlight its potential impacts on the oncogene network. These findings on mir-17-92 indicate that miRNAs, together with protein coding genes, are integrated components of the molecular pathways that regulate tumor development and tumor maintenance.
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影响因子：
64.8
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