A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting.
A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting.
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DOI：
10.3390/gels8040239
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发表时间：
2022-04-13
期刊：
影响因子：
4.6
通讯作者：
Wang, Hongjun
中科院分区：
文献类型：
--
作者：
Ratnamani, Matangi Parimala Chelvi;Zhang, Xinping;Wang, Hongjun
关键词：
在过去的几十年里，再生医学领域出现了指数级增长。开始时是摘除性的（完全的组织或器官切除），很少考虑组织损失和/或毁容的影响，已经发展到使用个性化的活细胞制造工程化组织（例如，干细胞），并定制基质或结构组织来支持和引导组织发育。主要通过三维（3D）打印技术实现的生物织物提供细胞和生物材料的精确、受控和分层的组装，模拟体内组织结构的异质微环境。这篇综述为生物制造过程提供了一个简明的框架，并讨论了水凝胶对生物建模的贡献。水凝胶在生物打印中的多功能性是详细的沿着其物理，机械和生物特性的广泛阐述，以及它们在生物打印中的资产和限制。通过生物制造3D结构的案例研究，讨论了各种水凝胶在组织形成中的范围，以便为读者提供生物医学科学突破障碍的成就的一瞥。最后，讨论了生物打印本身的限制，并提出了克服这些限制的工程策略。
The past a few decades have seen exponential growth in the field of regenerative medicine. What began as extirpative (complete tissue or organ removal), with little regard to the effects of tissue loss and/or disfigurement, has evolved towards fabricating engineered tissues using personalized living cells (e.g., stem cells), and customizing a matrix or structural organization to support and guide tissue development. Biofabrication, largely accomplished through three-dimensional (3D) printing technology, provides precise, controlled, and layered assemblies of cells and biomaterials, emulating the heterogenous microenvironment of the in vivo tissue architecture. This review provides a concise framework for the bio-manufacturing process and addresses the contributions of hydrogels to biological modeling. The versatility of hydrogels in bioprinting is detailed along with an extensive elaboration of their physical, mechanical, and biological properties, as well as their assets and limitations in bioprinting. The scope of various hydrogels in tissue formation has been discussed through the case studies of biofabricated 3D constructs in order to provide the readers with a glimpse into the barrier-breaking accomplishments of biomedical sciences. In the end, the restraints of bioprinting itself are discussed, accompanied with the identification of available engineering strategies to overcome them.
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影响因子：
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作者：
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