Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.
Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence.
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DOI：
10.1016/j.jshs.2022.01.004
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发表时间：
2022-11
影响因子：
11.7
通讯作者：
Huang, Jianfeng
中科院分区：
文献类型：
--
作者：
Liu, Qiong;Huang, Keyong;Liang, Fengchao;Yang, Xueli;Li, Jianxin;Chen, Jichun;Liu, Xiaoqing;Cao, Jie;Shen, Chong;Yu, Ling;Zhao, Yingxin;Deng, Ying;Li, Ying;Hu, Dongsheng;Lu, Xiangfeng;Liu, Yang;Gu, Dongfeng;Liu, Fangchao;Huang, Jianfeng
细颗粒物（PM2.5）改变了体力活动（PA）量和强度与高血压事件的相关性。在PM2.5暴露较低的情况下，PA增加可降低患高血压的风险。PA预防高血压的益处被高PM2.5暴露所否定或逆转。在高污染地区，定期体力活动（PA）的益处与增加暴露于空气污染的潜在有害影响之间的权衡仍不清楚。本研究的目的是检查是否环境细颗粒物（PM2.5）暴露修改PA的体积和强度对高血压风险的影响。我们纳入了中国动脉粥样硬化性心血管疾病风险预测（China-PAR）项目的全国队列中的54，797名基线无高血压的参与者。通过问卷调查评估PA体积和强度，并使用基于卫星的模型生成高分辨率（1 km ×1 km）PM2.5估计值。在413，516人年的随访中，确定了12，100例高血压事件。PM2.5显著改变了PA与高血压发病率的关系（P < 0.001）。在低PM2.5层（<59.8 μg/m3，ptrend < 0.001），PA体积增加与高血压事件呈负相关，当比较PA体积的第四和第一四分位数时，风险比为0.81（95%置信区间（95%CI）：0.74-0.88）。然而，在高PM2.5层（≥59.8 μg/m3，ptrend = 0.370）中并未观察到健康益处。此外，与轻度PA强度相比，对于暴露于低PM2.5水平的参与者，剧烈强度与高血压风险降低20%（95%CI：9%-29%）相关，但对于高PM2.5水平的参与者，高强度强度与高血压风险增加17%（95%CI：4%-33%）相关。PA仅在PM2.5暴露低的参与者中与高血压风险降低相关。我们的研究结果建议在污染较轻的地区定期使用PA来预防高血压，并强调了改善空气质量的重要性。
Fine particulate matter (PM2.5) modified the association of physical activity (PA) volume and intensity with incident hypertension. Risk of developing hypertension was reduced by increased PA with low PM2.5 exposure. The benefits of PA on hypertension prevention were negated or reversed by high PM2.5 exposure. The trade-off between the benefits of regular physical activity (PA) and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear. This study aimed to examine whether ambient fine particulate matter (PM2.5) exposure modified the impacts of PA volume and intensity on hypertension risk. We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project. PA volume and intensity were assessed by questionnaire, and high-resolution (1 km ×1 km) PM2.5 estimates were generated using a satellite-based model. During 413,516 person-years of follow-up, 12,100 incident hypertension cases were identified. PM2.5 significantly modified the relationship between PA and hypertension incidence (pinteraction < 0.001). Increased PA volume was negatively associated with incident hypertension in the low PM2.5 stratum (<59.8 μg/m3, ptrend < 0.001), with a hazard ratio of 0.81 (95% confidence interval (95%CI): 0.74–0.88) when comparing the fourth with the first quartile of PA volume. However, the health benefits were not observed in the high PM2.5 stratum (≥59.8 μg/m3, ptrend = 0.370). Moreover, compared with light PA intensity, vigorous intensity was related to a 20% (95%CI: 9%–29%) decreased risk of hypertension for participants exposed to low PM2.5, but a 17% (95%CI: 4%–33%) increased risk for those with high PM2.5 levels. PA was associated with a reduced risk of hypertension only among participants with low PM2.5 exposure. Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
10.4
作者：
Andersen ZJ;de Nazelle A;Mendez MA;Garcia-Aymerich J;Hertel O;Tjønneland A;Overvad K;Raaschou-Nielsen O;Nieuwenhuijsen MJ
通讯作者：
Nieuwenhuijsen MJ
中国长期接触细颗粒物与高血压发病率：China-PAR 队列研究
影响因子：
8.3
作者：
Huang, Keyong;Yang, Xueli;Gu, Dongfeng
通讯作者：
Gu, Dongfeng
影响因子：
39.3
作者：
Pelliccia, Antonio;Sharma, Sanjay;Wilhelm, Matthias
通讯作者：
Wilhelm, Matthias
DOI：
10.1164/rccm.201510-2036oc
发表时间：
2016-10-01
影响因子：
24.7
作者：
Fisher, Jack E.;Loft, Steffen;Andersen, Zorana J.
通讯作者：
Andersen, Zorana J.