Effects of pre-gestational diabetes mellitus and gestational diabetes mellitus on macrosomia and birth defects in Upstate New York.
Effects of pre-gestational diabetes mellitus and gestational diabetes mellitus on macrosomia and birth defects in Upstate New York.
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DOI：
10.1016/j.diabres.2019.107811
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发表时间：
2019-09
影响因子：
5.1
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Yang GR;Dye TD;Li D
目的探讨妊娠期糖尿病(PGDM)和妊娠期糖尿病(GDM)对巨大儿和出生缺陷的影响。对纽约州北部围产期数据系统现有的出生登记数据进行了分析。从2004年到2016年，650,914名年龄在18-55岁之间的单胎足月妊娠(≥37周)的女性被纳入其中。妊娠期糖尿病和妊娠期糖尿病孕妇所生婴儿巨大儿发生率分别为26.0%和16.4%，高于对照组(11.2%)。与对照组(0.8%)相比，妊娠期糖尿病组和妊娠期糖尿病组出生缺陷发生率(1.8%和1.0%)更高。PGDM组青紫型心脏病的患病率最高(0.6%)。与妊娠期糖尿病组和对照组相比，妊娠期糖尿病组唇腭裂、单纯腭裂、尿道下裂和肢体复位畸形的发生率更高(p<；0.05)。然而，妊娠期糖尿病组的这些出生缺陷与对照组相似。与对照组相比，妊娠期糖尿病和妊娠期糖尿病组巨大儿、青紫型心脏病和任何出生缺陷的几率都显著增加。PGDM组发生唇腭裂、单纯腭裂、尿道下裂和肢体复位畸形的几率较高。利用围产期数据系统数据库，在纽约州北部，妊娠期糖尿病和妊娠期糖尿病，尤其是妊娠期糖尿病，与巨大儿、紫癜性心脏病和任何单胎足月妊娠出生缺陷的发生率较高相关。妊娠期糖尿病患者唇腭裂、单纯腭裂、尿道下裂和肢体复位畸形的发生率高于妊娠期糖尿病患者。
To evaluate the effects of pre-gestational diabetes mellitus (PGDM) and gestational diabetes mellitus (GDM) on macrosomia and birth defects. Existing birth registry data from the Perinatal Data System in Upstate New York was analysed. 650,914 women with a singleton term pregnancy (≥37 weeks) aged 18–55 years from 2004 to 2016 were included. The prevalence of macrosomia in infants born to women with PGDM and GDM were 26.0% and 16.4%, respectively, higher than that in the controls (11.2%). Compared with the controls (0.8%), the PGDM and GDM groups had higher prevalence of any birth defect (1.8% and 1.0%). The PGDM group had the highest prevalence of cyanotic heart disease (0.6%). Moreover, the PGDM group had higher prevalence of cleft lip and palate, cleft palate alone, hypospadias and limb reduction defect compared to the GDM and control groups (p < 0.05). However, these birth defects in the GDM group were similar to those in the controls. Both the PGDM and GDM groups had significantly elevated odds of macrosomia, cyanotic heart disease and any birth defect than controls. The PGDM group had higher odds of cleft lip and palate, cleft palate alone, hypospadias and limb reduction defect. Using the Perinatal Data System database, PGDM and GDM, especially PGDM, was associated with higher prevalence of macrosomia, cyanotic heart disease and any birth defect in singleton term pregnancy in Upstate New York. PGDM, not GDM had higher prevalence of cleft lip and palate, cleft palate alone, hypospadias and limb reduction defect.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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