Association between an insertion/deletion polymorphism in the interleukin-1α gene and the risk of colorectal cancer in a Chinese population
Association between an insertion/deletion polymorphism in the interleukin-1α gene and the risk of colorectal cancer in a Chinese population
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白细胞介素-1α基因插入/缺失多态性与中国人群结直肠癌风险的关联
DOI：
10.1177/1724600818785069
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Yufang Wang
中科院分区：
文献类型：
--
作者：
Qizhao Ma;Zhigang Mao;Jipei Du;Shiping Liao;Yanjiang Zheng;Maohui Zhi;Ji Zhang;Yufang Wang
Background: Previous studies have reported that polymorphisms in the interleukin-1 gene may be involved in tumorigenesis and tumor progression. Aim: The purpose of the present study was to evaluate whether an insertion/deletion polymorphism, rs3783553, located in the miR-122 target gene interleukin-1α, was associated with the risk of colorectal cancer. Methods: Genomic DNA was extracted from peripheral venous blood of 382 patients with colorectal cancer and 433 controls, and the polymorphism was genotyped using a polymerase chain reaction assay. Results: Significantly decreased colorectal cancer risk was observed to be associated with the interleukin-1α rs3783553 insertion/insertion genotype (P=0.0001; OR=0.41; 95% CI 0.26, 0.65) and the insertion allele (P<0.001; OR=0.68; 95% CI 0.55, 0.83). Stratification analysis based on clinical and pathological features also revealed that the “TTCA” insertion allele of rs3783553 contributes to slow the progression of colorectal cancer. Conclusion: These results suggest that the rs3783553 polymorphism could be a useful genetic marker to predict the size/extent of colorectal cancer.
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影响因子：
4.7
作者：
Gao, Lin-Bo;Rao, Li;Zhang, Lin
通讯作者：
Zhang, Lin
影响因子：
2.2
作者：
Zhu Zhang;Bin Zhou;Qianqian Gao;Yuke Wu;Kui Zhang;Yan Pu;Yaping Song;Lin Zhang;M. Xi
通讯作者：
Zhu Zhang;Bin Zhou;Qianqian Gao;Yuke Wu;Kui Zhang;Yan Pu;Yaping Song;Lin Zhang;M. Xi
影响因子：
--
作者：
M. Sioud
通讯作者：
M. Sioud
DOI：
10.4238/gmr.15017486
发表时间：
2016-02
期刊：
Genetics and molecular research : GMR
影响因子：
--
作者：
Xin Huang;Yuqiu Yang;Cui Zw;J. Wang;Linbo Gao
通讯作者：
Xin Huang;Yuqiu Yang;Cui Zw;J. Wang;Linbo Gao
影响因子：
4.7
作者：
Landi, Debora;Gemignani, Federica;Landi, Stefano
通讯作者：
Landi, Stefano