Effects of interval between age at first pregnancy and age at diagnosis on breast cancer survival according to menopausal status: a register-based study in Korea.
Effects of interval between age at first pregnancy and age at diagnosis on breast cancer survival according to menopausal status: a register-based study in Korea.
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DOI：
10.1186/1472-6874-14-113
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发表时间：
2014-09-18
期刊：
影响因子：
--
通讯作者：
Korean Breast Cancer Society
中科院分区：
文献类型：
--
作者：
Lee J;Oh M;Korean Breast Cancer Society
胎次和首次怀孕年龄（AFP）与诊断年龄之间的时间间隔对乳腺癌生存的影响与它们对乳腺癌风险的影响不同。我们的目的是调查韩国绝经前和绝经后妇女的时间间隔或胎次与预后的关系。我们通过韩国乳腺癌登记处从1993年到2009年对29167名乳腺癌妇女进行了回顾性研究。关于生殖因素的信息，包括母乳喂养、AFP和胎次，从常规问卷中收集。使用条件logistic回归来估计绝经状态与总死亡率（OM）和乳腺癌特异性死亡率（BCSM）之间的关系，并根据治疗和分期进行调整。高胎次（≥5胎次）增加了绝经前和绝经后妇女BCSM （HR = 1.33, 95%可信区间（CI）： 0.83-2.11, p <0.001）和OM （HR = 1.20, 95% CI: 0.85-1.68.73, p <0.001）的危险比（BCSM, HR: 1.62, 95% CI: 0.93-2.82, p <0.001； OM, HR = 1.58, 95% CI: 1.14-2.21, p <0.001）。较长的乳腺癌诊断年龄与AFP之间的时间间隔降低了绝经前妇女BCSM （HR = 0.97, 95% CI: 0.96-0.98, p = 0.001）和OM （HR = 0.98, 95% CI: 0.97 - 0.98, p < 0.001）的HR，但对绝经后妇女OM （HR = 1.03, 95% CI: 1.02-1.03, p < 0.001）的HR有不利影响。在绝经前和绝经后妇女中，高胎次（≥5胎次）与乳腺癌预后不良相关。生殖活动之间的时间间隔对乳腺癌的预后有不同的影响，这取决于绝经状态。本文的在线版本（doi:10.1186/1472-6874-14-113）包含补充材料，可供授权用户使用。
The influence of parity and time interval between age at first pregnancy (AFP) and age at diagnosis on breast cancer survival is not established in the same way as their influence on breast cancer risk. We aimed to investigate the association of time interval or parity with prognosis in pre- and postmenopausal women in Korea. We conducted a retrospective study of 29,167 women with breast cancer through the Korean Breast Cancer Registry from 1993–2009. Information on reproductive factors, including breastfeeding, AFP, and parity were collected from a routine questionnaire. Conditional logistic regression was used to estimate the associations between menopausal status and overall mortality (OM) and breast-cancer-specific mortality (BCSM), adjusting for treatment and stage. High parity (≥5) increased the hazard ratios (HR) of BCSM (HR = 1.33, 95% confidence interval (CI): 0.83–2.11, p < 0.001) and OM (HR = 1.20, 95% CI: 0.85–1.68.73, p < 0.001) in premenopausal and postmenopausal women (BCSM, HR: 1.62, 95% CI: 0.93–2.82, p < 0.001; OM, HR = 1.58, 95% CI: 1.14–2.21, p <0.001). A longer time interval between age at breast cancer diagnosis and AFP reduced the HRs of BCSM (HR = 0.97, 95% CI: 0.96–0.98, p = 0.001) and OM (HR = 0.98, 95% CI: 0.97–0.98, p < 0.001) in premenopausal women, but had an adverse effect on the HR of OM (HR = 1.03, 95% CI: 1.02–1.03, p < 0.001) in postmenopausal women. High parity (≥5) was associated with poor breast cancer prognosis in both pre- and postmenopausal women. The time intervals between reproductive events had different effects on breast cancer outcomes depending on menopausal status. The online version of this article (doi:10.1186/1472-6874-14-113) contains supplementary material, which is available to authorized users.
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