New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing Brain.
New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing Brain.
复制标题
DOI：
10.1002/bdr2.1085
复制
发表时间：
2017-07-17
影响因子：
2.1
通讯作者：
Weissman MM
中科院分区：
文献类型：
--
作者：
Gingrich JA;Malm H;Ansorge MS;Brown A;Sourander A;Suri D;Teixeira CM;Caffrey Cagliostro MK;Mahadevia D;Weissman MM
发育经历了敏感期，在此期间，可塑性允许遗传和环境因素对生物体的成熟施加不可磨灭的影响。在中枢神经系统(CNS)发育的背景下，这种敏感期塑造了调节、调节和控制行为的神经回路的形成。这一一般机制使发展既可以由遗传蓝图指导，也可以由环境背景指导。在允许适应的同时，这种敏感期也是脆弱的窗口，在此期间，外部和内部因素可能会通过破坏适应性发展计划而增加大脑疾病的风险。我们小组对对5-羟色胺(5-HT)信号敏感的发育期以及与精神病学相关的影响行为和认知特别感兴趣。具体地说，我们回顾了影响额叶边缘系统发育的5-羟色胺敏感期，导致认知、焦虑和抑郁相关行为。我们讨论临床前数据以建立生物学上的可信性和机制上的洞察力。我们还总结了流行病学结果，强调了目前在怀孕期间开5-羟色胺再摄取抑制抗抑郁药的做法对公众健康的潜在影响。这些药物进入胎儿循环，可能扰乱大脑中的5-羟色胺信号，并可能以与我们在发育中的啮齿动物大脑中的发现相似的方式影响电路成熟。需要更多的研究来更好地区分母体症状对胎儿和儿童发育的双重影响与5-羟色胺再摄取抑制剂对子代临床结局的影响。
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system (CNS) development, such sensitive periods shape the formation of neuro-circuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint, as well as the environmental context. While allowing for adaptation, such sensitive periods are also windows of vulnerability during which external and internal factors can confer risk to brain disorders by derailing adaptive developmental programs. Our group has been particularly interested in developmental periods that are sensitive to serotonin (5-HT) signaling, and impact behavior and cognition relevant to psychiatry. Specifically, we review a 5-HT-sensitive period that impacts fronto-limbic system development, resulting in cognitive, anxiety, and depression-related behaviors. We discuss preclinical data to establish biological plausibility and mechanistic insights. We also summarize epidemiological findings that underscore the potential public health implications resulting from the current practice of prescribing 5-HT reuptake inhibiting antidepressants during pregnancy. These medications enter the fetal circulation, likely perturb 5-HT signaling in the brain, and may be affecting circuit maturation in ways that parallel our findings in the developing rodent brain. More research is needed to better disambiguate the dual effects of maternal symptoms on fetal and child development from the effects of 5-HT reuptake inhibitors on clinical outcomes in the offspring.
登录
查看更多内容
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
影响因子：
3.3
作者：
Bonnin, A.;Peng, W.;Levitt, P.
通讯作者：
Levitt, P.
影响因子：
120.7
作者：
Cohen, LS;Altshuler, LL;Stowe, ZN
通讯作者：
Stowe, ZN
影响因子：
3.4
作者：
Diav-Citrin, Orna;Shechtman, Svetlana;Ornoy, Asher
通讯作者：
Ornoy, Asher
影响因子：
25.8
作者：
Brown, Alan S.;Gyllenberg, David;Sourander, Andre
通讯作者：
Sourander, Andre