Defective Interfering RNAs: Foes of Viruses and Friends of Virologists.
Defective Interfering RNAs: Foes of Viruses and Friends of Virologists.
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DOI：
10.3390/v1030895
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Nagy PD
中科院分区：
文献类型：
--
作者：
Pathak KB;Nagy PD
缺陷性干扰（DI）RNA是在RNA病毒通过易错病毒复制酶增殖过程中产生的亚病毒RNA。DI-RNA是源自亲本病毒并与亲本病毒相关的寄生RNA，其利用病毒编码的蛋白质因子进行增殖。DI-RNA生物学领域的最新进展使人们对DI-RNA的产生和进化以及症状减轻的机制有了更深入的了解。此外，DI-RNA是病毒学家手中的多功能工具，并用作不太复杂的替代模板来了解其辅助病毒的生物学。它们易于遗传操作，导致快速发现复制和重组所需的顺式作用RNA复制元件。DI-RNA已被进一步利用，以发现调节番茄丛矮病毒复制以及病毒RNA重组的宿主因子。本文综述了DI-RNA的产生和进化模型、病毒和宿主因子在DI-RNA复制中的作用以及疾病减毒机制。
Defective interfering (DI) RNAs are subviral RNAs produced during multiplication of RNA viruses by the error-prone viral replicase. DI-RNAs are parasitic RNAs that are derived from and associated with the parent virus, taking advantage of viral-coded protein factors for their multiplication. Recent advances in the field of DI RNA biology has led to a greater understanding about generation and evolution of DI-RNAs as well as the mechanism of symptom attenuation. Moreover, DI-RNAs are versatile tools in the hands of virologists and are used as less complex surrogate templates to understand the biology of their helper viruses. The ease of their genetic manipulation has resulted in rapid discoveries on cis-acting RNA replication elements required for replication and recombination. DI-RNAs have been further exploited to discover host factors that modulate Tomato bushy stunt virus replication, as well as viral RNA recombination. This review discusses the current models on generation and evolution of DI-RNAs, the roles of viral and host factors in DI-RNA replication, and the mechanisms of disease attenuation.
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