The evolution of metazoan extracellular matrix.

The evolution of metazoan extracellular matrix.
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DOI:
10.1083/jcb.201109041
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发表时间:
2012-03-19
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Hynes RO
Hynes RO
中科院分区:
其他
文献类型:
--
作者:
Hynes RO

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细胞外基质(ECM)蛋白及其基因的模块结构域在进化过程中允许广泛的外显子/结构域重排,从而产生了数百种ECM蛋白。其中许多蛋白在后生动物进化早期就已出现,并且从那时起就高度保守。其他蛋白在进化过程中经历了复制和分化,并且结构域的新组合不断进化产生新的ECM蛋白,特别是在脊椎动物谱系中。最近对几个基因组的测序揭示了ECM蛋白这种保守性和进化的许多细节,以服务于后生动物的多种功能。
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa.
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