Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.
Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.
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DOI：
10.1016/j.jpainsymman.2016.08.005
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发表时间：
2017-01
影响因子：
4.7
通讯作者：
Park J
中科院分区：
文献类型：
--
作者：
Reich RR;Lengacher CA;Alinat CB;Kip KE;Paterson C;Ramesar S;Han HS;Ismail-Khan R;Johnson-Mallard V;Moscoso M;Budhrani-Shani P;Shivers S;Cox CE;Goodman M;Park J
乳腺癌幸存者 (BCS) 面临着不良的身体和心理症状，而且这些症状常常同时发生。生物和心理因素可能将集群内的症状联系起来，可通过患病率和/或严重程度来区分。很少有研究探讨行为干预或症状群治疗的效果。本研究的目的是确定治疗后 BCS 中的症状群，并确定乳腺癌正念减压 (MBSR(BC)) 计划后症状群的改善情况。 322 例 0-III 期治疗后 BCS 被随机分配至为期六周的 MBSR（BC）计划或常规护理。在基线、第 6 周和第 12 周评估心理（抑郁、焦虑、压力和对复发的恐惧）、身体（疲劳、疼痛、睡眠和嗜睡）和认知症状和生活质量，以及基线时的人口统计和临床历史数据。三步分析过程包括因子分析和结构方程建模的误差核算模型。基线时出现了四种症状群：疼痛、心理、疲劳和认知。从基线到六周，该模型证明了 MBSR（BC）在心理（焦虑、抑郁、感知压力和生活质量、情绪健康）（P = 0.007）和疲劳（疲劳、睡眠和嗜睡）（P < 0.001）集群中的有效性。 6 至 12 周的结果显示出持续的效果，但没有观察到进一步的改善。我们的结果提供了临床有效性证据，表明MBSR（BC）可以改善症状群，特别是心理和疲劳症状群，在为期六周的计划中出现最大的改善，并在MBSR（BC）训练后持续数周。注册中心名称和 URL：ClinicalTrials.gov。注册号：NCT01177124。
Breast cancer survivors (BCS) face adverse physical and psychological symptoms, often co-occurring. Biologic and psychological factors may link symptoms within clusters, distinguishable by prevalence and/or severity. Few studies have examined the effects of behavioral interventions or treatment of symptom clusters. The aim of this study was to identify symptom clusters among post-treatment BCS and determine symptom cluster improvement following the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) program. Three hundred twenty-two Stage 0–III post-treatment BCS were randomly assigned to either a six-week MBSR(BC) program or usual care. Psychological (depression, anxiety, stress, and fear of recurrence), physical (fatigue, pain, sleep, and drowsiness), and cognitive symptoms and quality of life were assessed at baseline, six, and 12 weeks, along with demographic and clinical history data at baseline. A three-step analytic process included the error-accounting models offactor analysis and structural equation modeling. Four symptom clusters emerged at baseline: pain, psychological, fatigue, and cognitive. From baseline to six weeks, the model demonstrated evidence of MBSR(BC) effectiveness in both the psychological (anxiety, depression, perceived stress and QOL, emotional well-being) (P = 0.007) and fatigue (fatigue, sleep, and drowsiness) (P < 0.001) clusters. Results between six and 12 weeks showed sustained effects, but further improvement was not observed. Our results provide clinical effectiveness evidence that MBSR(BC) works to improve symptom clusters, particularly for psychological and fatigue symptom clusters, with the greatest improvement occurring during the six-week program with sustained effects for several weeks after MBSR(BC) training. Name and URL of Registry: ClinicalTrials.gov. Registration number: NCT01177124.
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DOI：
10.1007/s11764-009-0100-7
发表时间：
2009-12
期刊：
Journal of cancer survivorship : research and practice
影响因子：
--
作者：
Fu OS;Crew KD;Jacobson JS;Greenlee H;Yu G;Campbell J;Ortiz Y;Hershman DL
通讯作者：
Hershman DL
影响因子：
4.7
作者：
Carpenter, JS;Andrykowski, MA
通讯作者：
Andrykowski, MA
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.7
作者：
Ho SY;Rohan KJ;Parent J;Tager FA;McKinley PS
通讯作者：
McKinley PS