Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration.
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration.
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干细胞和外泌体：椎间盘退变的新疗法。
DOI：
10.3390/cells10092241
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发表时间：
2021-08-29
期刊：
影响因子：
6
通讯作者：
Gazit Z
中科院分区：
文献类型：
--
作者：
Krut Z;Pelled G;Gazit D;Gazit Z
椎间盘退变（IVDD）的发生是由于椎间盘合成代谢和分解代谢过程的不平衡，导致细胞外基质（ECM）组成的改变，髓核（NP）细胞的损失，过度氧化应激和炎症。随着年龄的增长，IVD的退化自然发生，但机械创伤、生活方式因素和某些遗传异常可增加症状性疾病进展的可能性。IVDD，通常被称为退行性椎间盘疾病（DDD），由于人口老龄化和美国肥胖发病率的增加，IVDD造成了越来越大的经济负担。目前IVDD的治疗包括药物和手术干预，但这些都缺乏阻止疾病进展和恢复IVD功能的能力。生物疗法已被评估，但在长期逆转椎间盘退变方面显示不同程度的疗效。基于干细胞的治疗方法在IVD再生方面已经显示出有希望的结果，但面临生物学和伦理上的限制。外泌体在细胞间通讯中起着重要作用，干细胞来源的外泌体已被证明可以保持其原始细胞的治疗益处而没有相关风险。这篇综述强调了干细胞来源的外泌体在IVDD治疗中的研究现状。
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in the intervertebral disc, leading to an alteration in the composition of the extracellular matrix (ECM), loss of nucleus pulposus (NP) cells, excessive oxidative stress and inflammation. Degeneration of the IVD occurs naturally with age, but mechanical trauma, lifestyle factors and certain genetic abnormalities can increase the likelihood of symptomatic disease progression. IVDD, often referred to as degenerative disc disease (DDD), poses an increasingly substantial financial burden due to the aging population and increasing incidence of obesity in the United States. Current treatments for IVDD include pharmacological and surgical interventions, but these lack the ability to stop the progression of disease and restore the functionality of the IVD. Biological therapies have been evaluated but show varying degrees of efficacy in reversing disc degeneration long-term. Stem cell-based therapies have shown promising results in the regeneration of the IVD, but face both biological and ethical limitations. Exosomes play an important role in intercellular communication, and stem cell-derived exosomes have been shown to maintain the therapeutic benefit of their origin cells without the associated risks. This review highlights the current state of research on the use of stem-cell derived exosomes in the treatment of IVDD.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Eldh M;Ekström K;Valadi H;Sjöstrand M;Olsson B;Jernås M;Lötvall J
通讯作者：
Lötvall J