Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription.
Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription.
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DOI：
10.1016/j.bbagrm.2012.02.015
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发表时间：
2012-07
影响因子：
4.7
通讯作者：
Adelman, Karen
中科院分区：
文献类型：
--
作者：
Gilchrist, Daniel A.;Adelman, Karen
改变基因表达以响应刺激是生物体执行发育程序和响应环境变化的关键机制。启动子DNA包装到染色质中可以极大地影响RNA聚合酶II转录基因的能力。因此，启动子染色质环境在建立适合于特定环境条件或发育状态的转录输出中起核心作用。最近的基因组研究阐明了染色质组织的一般原则，加深了我们对启动子序列和核小体结构如何影响基因表达的理解。同时，在早期延伸过程中聚合酶的暂停已被认为是影响刺激响应网络内基因转录的重要事件。现在认为，通过暂停调节的启动子具有独特的染色质结构，可以促进响应信号事件的基因表达的可塑性。在这里，我们回顾了在理解染色质和暂停方面的进展，并探索如何将Pol II暂停与不同的启动子架构结合起来，帮助生物体实现灵活而精确的转录控制。
Altering gene expression in response to stimuli is a critical mechanism through which organisms execute developmental programs and respond to changes in their environment. Packaging of promoter DNA into chromatin can greatly impact the ability of RNA polymerase II to transcribe a gene. Promoter chromatin environments thus play a central role in establishing transcriptional output appropriate for specific environmental conditions or developmental states. Recent genomic studies have illuminated general principles of chromatin organization and deepened our understanding of how promoter sequence and nucleosome architecture may impact gene expression. Concurrently, pausing of polymerase during early elongation has been recognized as an important event influencing transcription of genes within stimulus-responsive networks. Promoters regulated by pausing are now recognized to possess a distinct chromatin architecture that may facilitate the plasticity of gene expression in response to signaling events. Here we review advances in understanding chromatin and pausing, and explore how coupling Pol II pausing to distinct promoter architectures may help organisms achieve flexible yet precise transcriptional control.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
5.3
作者：
GILMOUR, DS;LIS, JT
通讯作者：
LIS, JT
影响因子：
5.3
作者：
Lee, Chanhyo;Li, Xiaoyong;Gilmour, David S.
通讯作者：
Gilmour, David S.
DOI：
10.1126/science.1181421
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Nechaev S;Fargo DC;dos Santos G;Liu L;Gao Y;Adelman K
通讯作者：
Adelman K
影响因子：
64.5
作者：
Rahl PB;Lin CY;Seila AC;Flynn RA;McCuine S;Burge CB;Sharp PA;Young RA
通讯作者：
Young RA