Importance of the time interval between FEV1 measurements in a methacholine provocation test.
Importance of the time interval between FEV1 measurements in a methacholine provocation test.
复制标题
在乙酰胆碱激发试验中 FEV1 测量之间的时间间隔的重要性。
DOI：
10.1016/s0012-3692(16)47463-5
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
W. Zhiping
中科院分区：
文献类型：
--
作者：
Per Malmberg;Kjell Larsson;B. Sundblad;W. Zhiping
We examined the hypothesis that a forced expiratory volume in one second (FEV1) manoeuvre (and the preceding deep inhalation) before inhalation of methacholine might influence FEV1 measured after methacholine, if the time between measurements was short. Six to nine healthy subjects inhaled a single dose of methacholine, known to cause about 20% decrease in FEV1, on different days in different test protocols. If an FEV1 manoeuvre was performed immediately before methacholine, the first FEV1 measured 3 min after provocation was higher (77% of basal FEV1) than if a pre-methacholine FEV1 manoeuvre was not performed (64%). This effect of a pre-methacholine FEV1 manoeuvre was also demonstrated at 2, 4 and 6, but not at 10 min after the start of methacholine inhalation. If an FEV1 manoeuvre was not performed before methacholine, the second and subsequent FEV1 measured in constricted airways was higher than the first, and of similar magnitude to the first FEV1 in tests where a pre-challenge FEV1 manoeuvre was performed. In another trial, 10 healthy subjects performed two stepwise methacholine tests, with either 6 or 3 min between dose steps. The percentage decrease in FEV1 per mg of inhaled methacholine decreased from 2.6 (1.9-5.2) to 1.7 (0.8-2.3) (median, interquartile-range) when the time interval was shortened. The results suggest that the deep inhalation associated with the FEV1 manoeuvre decreases the bronchial tone in airways constricted by methacholine for up to 6 min, possibly due to yielding of cross-links in airway smooth muscles.
气道和肺实质反冲滞后的时间依赖性。
DOI：
10.1152/jappl.1986.61.1.248
发表时间：
1986
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Fairshter,RD;Berry,RB;Wilson,AF;Lowe,JE
通讯作者：
Lowe,JE
正常受试者和患有慢性气流阻塞的个体的气道滞后。
DOI：
10.1152/jappl.1985.58.5.1505
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Fairshter,RD
通讯作者：
Fairshter,RD
DOI：
10.1152/jappl.1982.52.3.655
发表时间：
1982
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Gunst,SJ;Russell,JA
通讯作者：
Russell,JA