Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.
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DOI：
10.1016/j.neuroimage.2008.07.013
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发表时间：
2008-11-15
期刊：
影响因子：
5.7
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Hua X;Leow AD;Parikshak N;Lee S;Chiang MC;Toga AW;Jack CR Jr;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
在迄今为止最大的脑MRI研究之一中，我们使用基于张量的形态测量(TBM)创建了676名阿尔茨海默病(AD)、轻度认知障碍(MCI)患者和健康老年对照组的结构萎缩3D地图，作为阿尔茨海默病神经成像倡议(ADNI)的一部分进行扫描。使用逆一致性3D非线性弹性图像配准，我们将676个个体大脑MRI体积扭曲到一个总体平均几何模板。创建了雅可比行列式地图，揭示了局部体积膨胀和压缩的3D轮廓。我们比较了165例AD患者(年龄：75.6±7.6岁)、330例MCI患者(74.8±7.5岁)和181例对照组(75.9±5.1岁)萎缩的解剖分布。选定感兴趣区的脑萎缩与体素水平的临床测量-临床痴呆症评分(CDR-SB)、简易精神状态检查(MMSE)和逻辑记忆测试分数-相关，然后进行多次比较校正。基线颞叶萎缩与现在的认知表现、未来的认知衰退以及在接下来的一年中从MCI到AD的转换相关；它预测未来的衰退，即使在健康的受试者中也是如此。超过一半的AD和MCI受试者携带ApoE4(载脂蛋白E4)基因，这增加了AD的风险；他们表现出比非携带者更大的海马区和颞叶缺陷。APOE2基因携带者--正常组的1/6--表现出减少的心室扩张，这表明了一种保护作用。作为一种自动化的图像分析技术，TBM揭示了神经成像标记物、基因和未来临床变化之间的3D相关性，对于大规模的MRI研究是高效的。
In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. Jacobian determinant maps were created, revealing the 3D profile of local volumetric expansion and compression. We compared the anatomical distribution of atrophy in 165 AD patients (age: 75.6 ± 7.6 years), 330 MCI subjects (74.8 ± 7.5), and 181 controls (75.9 ± 5.1). Brain atrophy in selected regions-of-interest was correlated with clinical measurements - the sum-of-boxes clinical dementia rating (CDR-SB), mini-mental state examination (MMSE), and the logical memory test scores - at voxel level followed by correction for multiple comparisons. Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects. Over half of the AD and MCI subjects carried the ApoE4 (apolipoprotein E4) gene, which increases risk for AD; they showed greater hippocampal and temporal lobe deficits than non-carriers. ApoE2 gene carriers - 1/6 of the normal group - showed reduced ventricular expansion, suggesting a protective effect. As an automated image analysis technique, TBM reveals 3D correlations between neuroimaging markers, genes, and future clinical changes, and is highly efficient for large-scale MRI studies.
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