Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
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DOI：
10.1038/npp.2009.111
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发表时间：
2010-01
期刊：
影响因子：
--
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经过几十年的研究，旨在阐明精神分裂症的病理生理学和病因学，它已经变得越来越明显，这是一种几乎没有界限的疾病。精神病理学表现跨越几个领域，影响受影响个体现实世界功能的多个方面。即使在这样一个领域，可以说是最持久的，难以治疗的，对长期功能的破坏性-执行障碍-不仅有一系列中断的组成过程，而且还有一个复杂的潜在功能失调的神经结构。此外，正如所涉及的大脑结构（例如，背外侧前额叶皮层）通过死后和神经成像技术继续证明多个相互作用的信号通路的改变，对遗传风险因素的理解也不断发展，表明疾病易患性的多个分子入口点。考虑到这种广泛的相互作用网络，本章采用系统水平的方法来研究精神分裂症中的执行功能障碍，通过确定额叶内外的关键区域，这些区域显示了精神分裂症的变化，并且在认知控制神经回路中很重要，总结了当前对其相关功能相互作用的认识，并回顾了精神分裂症风险遗传学与神经影像学方法观察到的特征性执行回路异常之间的新联系。
After decades of research aimed at elucidating the pathophysiology and etiology of schizophrenia, it has become increasingly apparent that it is an illness knowing few boundaries. Psychopathological manifestations extend across several domains, impacting multiple facets of real-world functioning for the affected individual. Even within one such domain, arguably the most enduring, difficult to treat, and devastating to long-term functioning – executive impairment – there are not only a host of disrupted component processes, but also a complex underlying dysfunctional neural architecture. Further, just as implicated brain structures (e.g., dorsolateral prefrontal cortex) via postmortem and neuroimaging techniques continue to demonstrate alterations in multiple, interacting signaling pathways, so too does evolving understanding of genetic risk factors suggest multiple molecular entry points to illness liability. With this expansive network of interactions in mind, the present chapter takes a systems-level approach to executive dysfunction in schizophrenia, by identifying key regions both within and outside of the frontal lobes that show changes in schizophrenia and are important in cognitive control neural circuitry, summarizing current knowledge of their relevant functional interactions, and reviewing emerging links between schizophrenia risk genetics and characteristic executive circuit aberrancies observed with neuroimaging methods.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Aalto, S;Brück, A;Rinne, JO
通讯作者：
Rinne, JO
影响因子：
--
作者：
Barbalat, Guillaume;Chambon, Valerian;Farrer, Chloee
通讯作者：
Farrer, Chloee
影响因子：
120.7
作者：
ANDREASEN, NC;FLASHMAN, L;YUH, WTC
通讯作者：
YUH, WTC
影响因子：
17.7
作者：
Akil, M;Pierri, JN;Lewis, DA
通讯作者：
Lewis, DA