Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks.
Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks.
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DOI：
10.1016/j.neuron.2022.04.013
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发表时间：
2022-07-06
期刊：
影响因子：
16.2
通讯作者：
Chang, Steve W. C.
中科院分区：
文献类型：
--
作者：
Dal Monte, Olga;Fan, Siqi;Fagan, Nicholas A.;Chu, Cheng-Chi J.;Zhou, Michael B.;Putnam, Philip T.;Nair, Amrita R.;Chang, Steve W. C.
社交目光互动有力地塑造了人际沟通。然而，与社会感知相比，人们对现实生活中社交凝视互动的神经元基础知之甚少。在这里，我们研究了灵长类前额叶-杏仁核网络中跨越四个区域的大量神经元，并证明了除了杏仁核之外，在眼眶额叶、背内侧前额叶和前扣带皮层中互动社交凝视的强大单细胞基础。这些区域的许多神经元在社会辨别力方面表现出高度的时间异质性，与观察同种物体相比存在选择性偏差。值得注意的是，每个大脑区域的很大一部分神经元以参数方式跟踪自己或他人的注视，为社交注视监测提供了基础。此外，几个神经元以特定于代理的方式显示出对相互目光接触的选择性编码。这些发现提供了证据，证明在社交凝视互动过程中，灵长类前额叶杏仁核网络中互动社交凝视神经元的广泛应用。达尔蒙特和范等人。研究了前额叶杏仁核网络中多个区域现实生活中社交凝视互动的单神经元机制。许多具有高度时间异质性的神经元跟踪自我或他人的注视，并表现出相互注视选择性，支持网络中交互式社交注视神经元的广泛实施。
Social gaze interaction powerfully shapes interpersonal communication. However, compared to social perception, very little is known about the neuronal underpinnings of real-life social gaze interaction. Here, we studied a large number of neurons spanning four regions in primate prefrontal-amygdala networks and demonstrate robust single-cell foundations of interactive social gaze in the orbitofrontal, dorsomedial prefrontal, and anterior cingulate cortices, in addition to the amygdala. Many neurons in these areas exhibited high temporal heterogeneity for social discriminability, with a selectivity bias for looking at a conspecific compared to an object. Notably, a large proportion of neurons in each brain region parametrically tracked the gaze of self or other, providing substrates for social gaze monitoring. Furthermore, several neurons displayed selective encoding of mutual eye contact in an agent-specific manner. These findings provide evidence of widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks during social gaze interaction. Dal Monte and Fan et al. investigated single-neuron mechanisms of real-life social gaze interaction in multiple regions in the prefrontal-amygdala networks. Many neurons with high temporal heterogeneity tracked the gaze of self or other and showed mutual gaze selectivity, supporting widespread implementations of interactive social gaze neurons in the networks.
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DOI：
10.1126/science.1194908
发表时间：
2010-11-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Freiwald WA;Tsao DY
通讯作者：
Tsao DY
影响因子：
25
作者：
Freiwald, Winrich A.;Tsao, Doris Y.;Livingstone, Margaret S.
通讯作者：
Livingstone, Margaret S.
影响因子：
25
作者：
Gangopadhyay P;Chawla M;Dal Monte O;Chang SWC
通讯作者：
Chang SWC
影响因子：
3.7
作者：
Kano F;Shepherd SV;Hirata S;Call J
通讯作者：
Call J
影响因子：
9.8
作者：
Basile, Benjamin M.;Schafroth, Jamie L.;Murray, Elisabeth A.
通讯作者：
Murray, Elisabeth A.