Prefrontal-amygdala circuits in social decision-making.

Prefrontal-amygdala circuits in social decision-making.
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DOI:
10.1038/s41593-020-00738-9
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发表时间:
2021-01
影响因子:
25
通讯作者:
Chang SWC
Chang SWC
中科院分区:
医学1区
文献类型:
--
作者:
Gangopadhyay P;Chawla M;Dal Monte O;Chang SWC

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越来越多的研究工作正致力于从系统神经科学的角度调查社会认知的神经基础。来自多个动物物种的证据开始在神经生物学的多个层面上提供对社会行为基底的机械理解,从人类的高级社会结构和猴子的更基本的基础到啮齿动物的社会行为的电路水平和细胞类型特定的实例。在这里,我们回顾文献研究人类,非人灵长类动物和啮齿动物的社会决策的神经机制,集中在杏仁核,内侧和眶前额叶皮质区及其功能的相互作用。我们还讨论了神经肽催产素如何影响这些回路及其对社会行为的下游影响。总体而言,我们的结论是,在前额叶-杏仁核通路中的神经元活动的调节相互作用对灵长类动物和啮齿类动物大脑中的社会决策做出了重要贡献。
An increasing amount of research effort is being directed toward investigating the neural bases of social cognition from a systems neuroscience perspective. Evidence from multiple animal species is beginning to provide a mechanistic understanding of the substrates of social behaviors at multiple levels of neurobiology, ranging from those underlying high-level social constructs in humans and their more rudimentary underpinnings in monkeys to circuit-level and cell-type specific instantiations of social behaviors in rodents. Here, we review literature examining the neural mechanisms of social decision-making in humans, nonhuman primates, and rodents, focusing on the amygdala, medial and orbital prefrontal cortical regions and their functional interactions. We also discuss how the neuropeptide oxytocin impacts these circuits and their downstream effects on social behaviors. Overall, we conclude that regulated interactions of neuronal activity in the prefrontal-amygdala pathways critically contribute to social decision-making in the brains of primates and rodents.
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