Prefrontal-amygdala circuits in social decision-making.
Prefrontal-amygdala circuits in social decision-making.
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DOI:
10.1038/s41593-020-00738-9
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发表时间:
2021-01
影响因子:
25
通讯作者:
Chang SWC
中科院分区:
文献类型:
--
作者:
Gangopadhyay P;Chawla M;Dal Monte O;Chang SWC
An increasing amount of research effort is being directed toward investigating the neural bases of social cognition from a systems neuroscience perspective. Evidence from multiple animal species is beginning to provide a mechanistic understanding of the substrates of social behaviors at multiple levels of neurobiology, ranging from those underlying high-level social constructs in humans and their more rudimentary underpinnings in monkeys to circuit-level and cell-type specific instantiations of social behaviors in rodents. Here, we review literature examining the neural mechanisms of social decision-making in humans, nonhuman primates, and rodents, focusing on the amygdala, medial and orbital prefrontal cortical regions and their functional interactions. We also discuss how the neuropeptide oxytocin impacts these circuits and their downstream effects on social behaviors. Overall, we conclude that regulated interactions of neuronal activity in the prefrontal-amygdala pathways critically contribute to social decision-making in the brains of primates and rodents.
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影响因子:
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DOI:
10.1073/pnas.1111715109
发表时间:
2012-02-07
影响因子:
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Tye KM