Biological functions of hCG and hCG-related molecules.
Biological functions of hCG and hCG-related molecules.
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DOI：
10.1186/1477-7827-8-102
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发表时间：
2010-08-24
期刊：
影响因子：
--
通讯作者：
Cole LA
中科院分区：
文献类型：
--
作者：
Cole LA
人绒毛膜促性腺激素是一个术语，指4个独立的分子，每个分子由不同的细胞产生，每个分子都具有完全不同的功能。这些hCG包括绒毛合体滋养层细胞产生的hCG、细胞滋养层细胞产生的高糖化hCG、多种原发非滋养细胞肿瘤产生的游离β亚基、以及垂体前叶促性腺激素细胞产生的hCG。人绒毛膜促性腺激素具有多种功能。人绒毛膜促性腺激素促进黄体细胞产生孕酮；促进子宫血管生成；促进细胞滋养细胞的融合和分化，使合体滋养细胞分化；阻断母亲对外来胎盘细胞的任何免疫或巨噬细胞作用；导致与胎儿生长平行的子宫生长；抑制怀孕期间的子宫肌层收缩；导致脐带的生长和分化；向子宫内膜发出即将着床的信号；作用于母亲大脑中的受体，导致妊娠剧吐，似乎还促进怀孕期间胎儿器官的生长。高糖基化的hCG可以促进细胞滋养层细胞的生长和侵袭，就像在妊娠植入和绒毛膜癌细胞的生长和侵袭中发生的那样。人绒毛膜促性腺激素(HCG)β亚基由多种不同原发的非滋养细胞恶性肿瘤产生。在这些恶性肿瘤中检测到游离的β-亚基通常被认为是预后不良的标志。游离的β-亚基阻止癌细胞的凋亡，促进癌症的生长和恶变。人绒毛膜促性腺激素是人绒毛膜促性腺激素的一种硫酸盐化变体，在月经周期中产生的水平较低。人绒毛膜促性腺激素似乎模拟了月经周期中促黄体生成激素的作用。
hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterior pituitary. hCG has numerous functions. hCG promotes progesterone production by corpus luteal cells; promotes angiogenesis in uterine vasculature; promoted the fusion of cytotrophoblast cell and differentiation to make syncytiotrophoblast cells; causes the blockage of any immune or macrophage action by mother on foreign invading placental cells; causes uterine growth parallel to fetal growth; suppresses any myometrial contractions during the course of pregnancy; causes growth and differentiation of the umbilical cord; signals the endometrium about forthcoming implantation; acts on receptor in mother's brain causing hyperemesis gravidarum, and seemingly promotes growth of fetal organs during pregnancy. Hyperglycosylated hCG functions to promote growth of cytotrophoblast cells and invasion by these cells, as occurs in implantation of pregnancy, and growth and invasion by choriocarcinoma cells. hCG free beta-subunit is produced by numerous non-trophoblastic malignancies of different primaries. The detection of free beta-subunit in these malignancies is generally considered a sign of poor prognosis. The free beta-subunit blocks apoptosis in cancer cells and promotes the growth and malignancy of the cancer. Pituitary hCG is a sulfated variant of hCG produced at low levels during the menstrual cycle. Pituitary hCG seems to mimic luteinizing hormone actions during the menstrual cycle.
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DOI：
10.1016/0006-291x(84)91228-2
发表时间：
1984-01-01
影响因子：
3.1
作者：
COLE, LA;PERINI, F;RUDDON, RW
通讯作者：
RUDDON, RW
影响因子：
4.8
作者：
Birken, S;Maydelman, Y;Hartree, AS
通讯作者：
Hartree, AS
影响因子：
4.8
作者：
Angelova, K;Fanelli, F;Puett, D
通讯作者：
Puett, D
影响因子：
5.8
作者：
AZUMA, K;CALDERON, I;HEALY, DL
通讯作者：
HEALY, DL
DOI：
10.1016/s0002-9378(98)70074-2
发表时间：
1998-09-01
影响因子：
9.8
作者：
Bahado-Singh, RO;Oz, U;Cole, L
通讯作者：
Cole, L