Glycan microarrays for decoding the glycome.

Glycan microarrays for decoding the glycome.
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DOI:
10.1146/annurev-biochem-061809-152236
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发表时间:
2011
影响因子:
16.6
通讯作者:
Paulson JC
Paulson JC
中科院分区:
生物学1区
文献类型:
--
作者:
Rillahan CD;Paulson JC

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In the last decade glycan microarrays have revolutionized the analysis of the specificity of glycan binding proteins, providing information that simultaneously illuminates the biology mediated by them and decodes the information content of the glycome. Numerous methods have emerged for arraying glycans in a ‘chip’ format, and glycan libraries have been assembled that address the diversity of the human glycome. Such arrays have been successfully used for analysis of glycan binding proteins that mediate mammalian biology, host-pathogen interactions, immune recognition of glycans relevant to vaccine production and cancer antigens. This review covers the development of glycan microarrays and applications that have provided insights into the roles of mammalian and microbial glycan binding proteins.
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