A single bout of torpor in mice protects memory processes.
A single bout of torpor in mice protects memory processes.
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DOI：
10.1016/j.physbeh.2009.02.013
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发表时间：
2009-04-20
影响因子：
2.9
通讯作者：
Sandstrom, Noah J.
中科院分区：
文献类型：
--
作者：
Nowakowski, Sarah G.;Swoap, Steven J.;Sandstrom, Noah J.
NOWAKOWSKI、S.G.、S.J.SWOAP 和 N.J.SANDSTROM。小鼠的一次麻木状态可以保护记忆过程。 PHYSIOL BEHAV 00(0) 000-000, 2008. – 记忆巩固是将新的、不稳定的信息稳定为长期记忆的过程。空间记忆的巩固被认为涉及信息从海马体到皮质区域的转移。虽然麻木的代谢低下和体温过低状态极大地改变了海马的连接性，但很少有工作考虑这些变化的功能后果。本研究探讨了单次浅麻木状态在小鼠记忆巩固过程中的作用。成年雌性 C57Bl/6NHSD 小鼠接受莫里斯水迷宫 (MWM) 任务的训练。获得后，小鼠立即接受四种实验操作之一24小时：在19°C的环境温度下禁食，在29°C下禁食，允许在19°C下自由进食，或允许在29°C下自由进食。通过核心体温评估，在 19°C 禁食的小鼠进入了一段麻木状态，而其他条件下的小鼠则没有出现这种情况。然后通过 MWM 中的探索试验评估空间偏差。在探测试验期间，进入麻木状态的小鼠和在 29°C 下进食的小鼠在先前目标平台位置上花费的时间是在 19°C 下进食和在 29°C 下禁食的小鼠的两倍。这些发现表明，虽然食物限制或凉爽的环境温度独立地破坏记忆过程，但它们共同引起生理变化，包括诱导麻木状态，从而导致记忆过程的功能保存。
NOWAKOWSKI, S. G., S. J. SWOAP, AND N. J. SANDSTROM. A single bout of torpor in mice protects memory processes. PHYSIOL BEHAV 00(0) 000-000, 2008. – Memory consolidation is the process by which new and labile information is stabilized as long-term memory. Consolidation of spatial memories is thought to involve the transfer of information from the hippocampus to cortical regions. While the hypometabolic and hypothermic state of torpor dramatically changes hippocampal connectivity, little work has considered the functional consequences of these changes. The present study examines the role of a single bout of shallow torpor in the process of memory consolidation in mice. Adult female C57Bl/6NHSD mice were trained on the Morris Water Maze (MWM) task. Immediately following acquisition, the mice were exposed to one of four experimental manipulations for 24 hours: fasted at an ambient temperature of 19°C, fasted at 29°C, allowed free access to food at 19°C, or allowed free access to food at 29°C. Mice fasted at 19°C entered a bout of torpor as assessed by core body temperature while none of the mice in the other conditions did so. Spatial biases were then assessed with a probe trial in the MWM. During the probe trial, mice that had entered torpor and mice that were fed at 29°C spent twice as much time in the prior target platform location than mice that were fed at 19°C and those that were fasted at 29°C. These findings demonstrate that, while food restriction or cool ambient temperature independently disrupt memory processes, together they cause physiological changes including the induction of a state of torpor that results in functional preservation of the memory process.
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影响因子：
2.9
作者：
Colbourne, F;Auer, RN;Sutherland, GR
通讯作者：
Sutherland, GR
影响因子：
3.4
作者：
Burman, Michael A.;Gewirtz, Jonathan C.
通讯作者：
Gewirtz, Jonathan C.
DOI：
10.1007/bf00263982
发表时间：
1996-07-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
影响因子：
--
作者：
Geiser, F;Song, X;Kortner, G
通讯作者：
Kortner, G
影响因子：
3.3
作者：
Hegde, P.;Singh, K.;Laxmi, T. R.
通讯作者：
Laxmi, T. R.
DOI：
10.1152/ajpregu.1998.275.5.r1627
发表时间：
1998-11-01
影响因子：
2.8
作者：
Geiser, F;Körtner, G;Schmidt, I
通讯作者：
Schmidt, I