Relationship between the geometry patterns of vertebrobasilar artery and atherosclerosis.
Relationship between the geometry patterns of vertebrobasilar artery and atherosclerosis.
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椎基底动脉几何形态与动脉粥样硬化的关系
DOI：
10.1186/s12883-018-1084-6
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发表时间：
2018-06-12
期刊：
影响因子：
2.6
通讯作者：
Xu WH
中科院分区：
文献类型：
--
作者：
Yu J;Zhang S;Li ML;Ma Y;Dong YR;Lou M;Feng F;Gao S;Wu SW;Xu WH
背景基底动脉（basilarartery，BA）背壁或侧壁的斑块与脑桥梗死相关。我们试图探讨椎基底动脉几何形状和BA斑块locations.MethodsWe回顾性分析了84例BA动脉粥样硬化患者的影像学和临床资料之间的相关性。在三维飞行时间图像上，评估双侧椎动脉（VA）的侧侧直径差和BA弯曲。椎基底动脉的几何形状被定性地分为四种基本构型：行走型、音叉型、显性-Lambda型和发育不全-Lambda型。在高分辨率磁共振成像上，斑块根据BA壁的腹侧、背侧或侧面的受累情况进行分类。椎基底动脉几何参数和斑块locations.Resultsleft VA优势28例（33%），和右VA优势22例（26%）患者之间的关系进行了分析。BA弯曲49例。VA直径的直径差/比值与斑块位置之间或BA弯曲与斑块位置之间无显著相关性。BA斑块均匀分布于椎基底动脉，呈音叉型和显性Lambda型。而在Lambda组中，斑块位于背壁（58.57%）多于腹壁（14.43%）和侧壁（26.71%;P= 0.001）。步行组斑块发生在外侧壁（49.79%）和背壁（35.07%）多于腹壁（14.86%，P = 0.02）。进一步的前瞻性研究是必要的，以证明是否Hypoplasia-Lambda和步行配置是脑桥梗死的独立危险因素。
BackgroundThe plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.MethodsWe retrospectively analyzed the imaging and clinical data of 84 patients with BA atherosclerosis. On three-dimensional time-of-flight images, a side to side diameter difference of bilateral vertebral artery (VA) and BA bending were assessed. The vertebrobasilar artery geometry was qualitatively classified into four basic configurations: Walking, Tuning Fork, Dominant-Lambda, and Hypoplasia-Lambda. On high-resolution magnetic resonance imaging, the plaques were categorized based on the involvement of the ventral, dorsal, or lateral sides of BA wall. The relationships between vertebrobasilar artery geometry parameters and plaque locations were analyzed.ResultsLeft VA dominance was identified in 28(33%) patients, and right VA dominance in 22(26%) patients. BA bending were detected in 49 patients. There were no significant correlations between the diameter difference/ratio of VA diameters and plaque locations, or between BA bending and plaque locations. BA plaques were evenly distributed in the vertebrobasilar arteries with Tuning Fork and Dominant-Lambda configurations. In Hypoplasia-Lambda group, however, plaques were more frequently located at the dorsal wall (58.57%) than at the ventral (14.43%) and lateral wall (26.71%;P= 0.001). In Walking group, the plaques more likely occurred at the lateral (49.79%) and dorsal (35.07%) wall than at the ventral wall (14.86%,P= 0.02).ConclusionsThe geometric configurations of vertebrobasilar artery strongly influence the BA plaque locations. Further prospective studies are warranted to testify whether Hypoplasia-Lambda and Walking configurations are independent risk factors for pontine infarcts.
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影响因子：
8.2
作者：
Kim BJ;Lee KM;Kim HY;Kim YS;Koh SH;Heo SH;Chang DI
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作者：
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