A challenge for the future: aging and HIV infection.
A challenge for the future: aging and HIV infection.
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DOI：
10.1007/s12026-010-8167-9
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发表时间：
2010-12
影响因子：
4.4
通讯作者：
Jamieson BD
中科院分区：
文献类型：
--
作者：
Rickabaugh TM;Jamieson BD
Older individuals (≥ 50 years of age) are increasingly becoming a new at-risk group for HIV-1 infection and, together with those surviving longer due to the introduction of anti-retroviral therapy (ART), it is predicted that more than half of all HIV-1-infected individuals in the U.S. will be greater than 50 years of age in the year 2015. Older individuals diagnosed with HIV-1 are prone to faster disease progression and reduced T-cell reconstitution despite successful virologic control with anti-retroviral therapy (ART). There is also growing evidence that the T-cell compartment in HIV-1+ adults displays an aged phenotype and HIV-1-infected individuals are increasingly diagnosed with clinical conditions more commonly seen in older uninfected persons. As aging in the absence of HIV infection is associated with alterations in T-cell function and immunosenescence, the combined impact of both HIV-1 infection and aging may provide an explanation for poorer clinical outcomes observed in older HIV-1-infected individuals. Thus, the development of novel therapeutics to stimulate immune function and delay immunosenescence is critical and would be beneficial to both the elderly and HIV-1 infected individuals.
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影响因子：
3.9
作者：
Appay, Victor;Almeida, Jorge R.;Papagno, Laura
通讯作者：
Papagno, Laura
影响因子：
3.7
作者：
Bodnar, AG;Kim, NW;Chiu, CP
通讯作者：
Chiu, CP
影响因子：
16.8
作者：
Appay, V;Rowland-Jones, SL
通讯作者：
Rowland-Jones, SL
影响因子：
1.5
作者：
Chattopadhyay, Pratip K.;Douek, Daniel C.;Margolick, Joseph B.
通讯作者：
Margolick, Joseph B.
DOI：
10.1097/qai.0b013e31817aebfe
发表时间：
2008-08-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
D'Souza G;Wiley DJ;Li X;Chmiel JS;Margolick JB;Cranston RD;Jacobson LP
通讯作者：
Jacobson LP