Evaluation of diethyl-3-3'-(9,10-anthracenediyl)bis acrylate as a probe for singlet oxygen formation during photodynamic therapy.
Evaluation of diethyl-3-3'-(9,10-anthracenediyl)bis acrylate as a probe for singlet oxygen formation during photodynamic therapy.
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DOI：
10.1111/j.1751-1097.2012.01106.x
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发表时间：
2012-05
影响因子：
3.3
通讯作者：
Price M
中科院分区：
文献类型：
--
作者：
Kessel D;Price M
细胞透过性的菲类似物-3-3‘-(9，10-蒽二基)双丙烯酸二乙酯(DADB)最近被认为是一种高选择性的单线态氧(1O2)探针。现在，我们证明了DADB可以用来监测光动力疗法期间细胞培养中的1O2形成。DADB的一个非典型特性是氧化后荧光发射减少。使用针对特定细胞器的光敏剂，我们确定DADB可以检测到1O2是否形成在内质网、线粒体或溶酶体中。然而，当光敏剂是名为WST11的钯细菌脱镁叶绿体时，DADB的荧光没有显著变化，据报道，这种光敏剂在水环境中照射时主要产生氧自由基，而在有机溶剂中形成单线态氧。
The cell-permeable anthracene analog diethyl-3-3′-(9,10-anthracenediyl)bis acrylate (DADB) was recently identified as a highly selective probe for singlet oxygen (1O2). Now, we show that DADB can be used to monitor 1O2 formation in cell culture during photodynamic therapy. An atypical property of DADB is that fluorescence emission is decreased upon oxidation. Using photosensitizers that target specific organelles, we determined that DADB could detect 1O2 whether formed in ER, mitochondria or lysosomes. DADB fluorescence was not, however, significantly altered when the photosensitizing agent was the palladium bacteriopheophorbide termed WST11, an agent reported to produce mainly oxygen radicals upon irradiation in an aqueous environment, whereas singlet oxygen was formed in organic solvents.
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影响因子：
3.3
作者：
Price M;Reiners JJ;Santiago AM;Kessel D
通讯作者：
Kessel D
影响因子：
3.3
作者：
Gollmer, Anita;Arnbjerg, Jacob;Ogilby, Peter R.
通讯作者：
Ogilby, Peter R.
影响因子：
7.4
作者：
Zielonka, Jacek;Kalyanaraman, B.
通讯作者：
Kalyanaraman, B.
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
4.8
作者：
Setsukinai, K;Urano, Y;Nagano, T
通讯作者：
Nagano, T