The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy.
The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy.
复制标题
抗生素抗生素抗生素的作用在尿路感染的发病机理中以及其使用噬菌体治疗的治疗潜力。
DOI：
10.3390/antibiotics10030281
复制
发表时间：
2021-03-09
期刊：
影响因子：
--
通讯作者：
Jończyk-Matysiak E
中科院分区：
文献类型：
--
作者：
Bagińska N;Cieślik M;Górski A;Jończyk-Matysiak E
鲍曼不动杆菌是属于关键优先群体的细菌，因为它们对碳青霉烯类和第三代头孢菌素具有耐药性，而第三代头孢菌素是最后机会的抗生素。日益增长的多重耐药性以及这些细菌形成生物膜的能力使得治疗该物种引起的感染变得困难，这种感染通常影响免疫缺陷患者或重症监护室患者。此外，大多数感染与患者插管有关。这些细菌尤其是尿路感染（UTI）的病原体，由于治疗困难以及复发的可能性，尿路感染（UTI）可能导致严重的医疗和社会问题，从而严重降低患者的生活质量。因此，噬菌体疗法是标准抗生素疗法的一种有前景的替代方案，它的成本更低，对治疗的患者来说更安全，并且真正有可能更有效。该综述的目的是概述耐药鲍曼不动杆菌在尿路感染发病机制中的重要作用，并强调用噬菌体疗法对抗这些感染的潜力。在动物模型中使用噬菌体治疗尿路感染的进一步研究可能会导致未来噬菌体治疗鲍曼不动杆菌引起的人类尿路感染的应用。
Acinetobacter baumannii are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics. The growing multi-drug resistance and the ability of these bacteria to form biofilms makes it difficult to treat infections caused by this species, which often affects people with immunodeficiency or intensive care unit patients. In addition, most of the infections are associated with catheterization of patients. These bacteria are causative agents, inter alia, of urinary tract infections (UTI) which can cause serious medical and social problems, because of treatment difficulties as well as the possibility of recurrence and thus severely decrease patients’ quality of life. Therefore, a promising alternative to standard antibiotic therapy can be bacteriophage therapy, which will generate lower costs and will be safer for the treated patients and has real potential to be much more effective. The aim of the review is to outline the important role of drug-resistant A. baumannii in the pathogenesis of UTI and highlight the potential for fighting these infections with bacteriophage therapy. Further studies on the use of bacteriophages in the treatment of UTIs in animal models may lead to the use of bacteriophage therapy in human urinary tract infections caused by A. baumannii in the future.
登录
查看更多内容
DOI：
10.1038/nrmicro3432
发表时间：
2015-05
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Flores-Mireles AL;Walker JN;Caparon M;Hultgren SJ
通讯作者：
Hultgren SJ
影响因子：
11.8
作者：
Cisneros, JM;Reyes, MJ;Cobacho, AR
通讯作者：
Cobacho, AR
影响因子：
16.6
作者：
Di Venanzio, Gisela;Flores-Mireles, Ana L.;Feldman, Mario F.
通讯作者：
Feldman, Mario F.
影响因子：
4.5
作者：
Cieślik M;Bagińska N;Górski A;Jończyk-Matysiak E
通讯作者：
Jończyk-Matysiak E
影响因子：
11.8
作者：
Cai, Tommaso;Nesi, Gabriella;Bartoletti, Riccardo
通讯作者：
Bartoletti, Riccardo