Exploration into the opinions of patients with HIV, healthcare professionals and the lay public of the use of microneedles in clinical practice: highlighting the translational potential for their role in HIV infection.
Exploration into the opinions of patients with HIV, healthcare professionals and the lay public of the use of microneedles in clinical practice: highlighting the translational potential for their role in HIV infection.
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DOI：
10.1007/s13346-020-00848-8
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发表时间：
2021-06
影响因子：
5.4
通讯作者：
Donnelly RF
中科院分区：
文献类型：
--
作者：
Moffatt K;Quinn C;McCague PJ;Donnelly RF
对口服抗逆转录病毒疗法(ART)依从性差仍然是艾滋病毒治疗中的一个重要挑战。微针(MN)可能提供一种非侵入性的长效(LA)给药方法，避免了每天服用ART的需要。然而，这一主张尚未在其潜在的最终用户中进行探索。这项混合方法研究的目的是调查不同最终用户围绕着将MN技术转化为一般临床实践的观点，特别是ART的交付。在卫生保健专业人员(HCP)和普通公众(LP)之间分发了定量的邮寄问卷。共获得208份回复(HCP，69份；LP，139份)，完成率为34.7%。两个人口学对MN技术的共识都是积极的(HCP，97.1%；LP，98.6%)，并进一步强烈支持假定在HIV中使用MN(HCP，97.1%；LP，98.6%)。采用定性焦点小组对12例HIV感染者进行深入调查。再次，对MN技术的共识是积极的，强调了与艾滋病毒相关的好处，包括谨慎的自我应用和潜在的持续释放，从而避免了日常口腔艺术和相关的副作用。患者关心的问题集中在需要不同的MN给药计划，以及不愿改变现有的ART。这项研究的结果从不同的最终用户人口统计中初步表明了MN的可接受性，特别是在艾滋病毒中的使用。此外，提出的关切主张在这一领域继续进行翻译研究的重要性，并应激励那些参与MN开发的人，以确保交付以患者为中心的MN产品。图形摘要
Poor adherence to oral antiretroviral therapy (ART) remains an important challenge in the treatment of HIV. Microneedles (MN) potentially could offer a non-invasive long-acting (LA) delivery approach, avoiding the need for daily dosing of ART. However, this claim has yet to be explored amongst its potential end-users. The aim of this mixed methods study was to investigate the perspectives from various end-users surrounding the translation of MN technology to general clinical practice, with a particular focus on delivery of ART. Quantitative postal questionnaires were distributed amongst healthcare professionals (HCPs) and the lay public (LP). A total of 208 responses were obtained (HCP, 69; LP, 139), with a completion rate of 34.7%. The consensus on MN technology was positive from both demographics (HCP, 97.1%; LP, 98.6%), with further strong support of postulated MN use within HIV (HCP, 97.1%; LP, 98.6%). Qualitative focus groups were employed to investigate in-depth, the perspectives of 12 patients with HIV. Again, consensus on MN technology was positive, highlighting benefits pertinent to HIV, including discreet self-application and potential sustained release thus avoiding daily oral ART and associated side effects. Patient concerns focused on the need for varied MN dosing schedules and a reluctance to change from established ART. The findings of this study provide an initial indication of MN acceptability, particularly for use within HIV, from various end-user demographics. Furthermore, concerns raised advocate the importance of continued translational research in this area and should act as motivators for those in MN development to ensure a patient-centred MN product is delivered. Graphical Abstract
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影响因子：
4.8
作者：
Edwards, Richard;Gifford, Heather;Wilson, Nick
通讯作者：
Wilson, Nick
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3.3
作者：
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Anderson, Claire
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作者：
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作者：
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通讯作者：
Crabtree, BF