Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
复制标题
DOI：
10.1016/j.nbd.2011.11.003
复制
发表时间：
2012-02
影响因子：
6.1
通讯作者：
Sweet, Robert A.
中科院分区：
文献类型：
--
作者：
Deo, Anthony J.;Cahill, Michael E.;Li, Siyu;Goldszer, Isaac;Henteleff, Ruth;VanLeeuwen, Jon-Eric;Rafalovich, Igor;Gao, Ruoqi;Stachowski, Erin K.;Sampson, Allan R.;Lewis, David A.;Penzes, Peter;Sweet, Robert A.
树突乔木长度和复杂性的减少是精神分裂症患者大脑皮层样本死后研究中神经元结构最一致的复制变化之一，然而，其潜在的分子机制尚未确定。这项研究是第一个确定调节蛋白Kalirin-9的改变，该蛋白已知可促进发育中神经元的树突长度和树枝化。我们发现Kalirin-9的表达在精神分裂症中矛盾地增加。我们通过在成熟的原代神经元培养物中过表达Kalirin-9来跟踪这一观察结果，导致树突长度和复杂性降低。Kalirin-9过表达代表了精神分裂症中树突状细胞变化的潜在机制。
Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mechanisms have not been identified. This study is the first to identify an alteration in a regulatory protein which is known to promote both dendritic length and arborization in developing neurons, Kalirin-9. We found Kalirin-9 expression to be paradoxically increased in schizophrenia. We followed up this observation by overexpressing Kalirin-9 in mature primary neuronal cultures, causing reduced dendritic length and complexity. Kalirin-9 overexpression represents a potential mechanism for dendritic changes seen in schizophrenia.
登录
查看更多内容
影响因子：
2.9
作者：
JAVITT, DC;STEINSCHNEIDER, M;AREZZO, JC
通讯作者：
AREZZO, JC
影响因子：
4.5
作者：
Broadbelt, K;Byne, W;Jones, LB
通讯作者：
Jones, LB
影响因子：
5.5
作者：
Larkum, ME;Zhu, JJ;Sakmann, B
通讯作者：
Sakmann, B
影响因子：
11
作者：
Hill, J. J.;Hashimoto, T.;Lewis, D. A.
通讯作者：
Lewis, D. A.
影响因子：
3.7
作者：
Ojima, Hisayuki;Honda, Christopher N.;Jones, Edward G.
通讯作者：
Jones, Edward G.