Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression.
Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression.
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DOI：
10.1186/1471-2407-9-274
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发表时间：
2009-08-07
期刊：
影响因子：
3.8
通讯作者：
Wan DQ
中科院分区：
文献类型：
--
作者：
Roth ES;Fetzer DT;Barron BJ;Joseph UA;Gayed IW;Wan DQ
众所周知，结肠直肠癌不经常转移到骨。这项回顾性研究的目的是确定结直肠癌是否绕过其他器官并直接转移到骨，以及肺部病变的存在是否上级肝脏作为骨转移可能性和时间的更好预测因素。我们对临床诊断为结肠癌的患者进行了回顾性分析，这些患者使用全身18F-FDG PET和CT或PET/CT进行分期。我们将252例患者的PET和CT报告与患者病史、其他成像方式和治疗相关信息相结合，以分析疾病进展。在诊断时，没有患者有孤立的骨转移，在我们的调查期间，没有患者发生孤立的骨转移而不累及其他器官。结直肠癌患者发生肺转移（23.3个月）或骨转移（21.2个月）的时间明显长于肝转移（9.8个月）。结论：在结直肠癌患者中，仅转移到骨而不累及其他器官是非常罕见的，可能比我们以前认为的更罕见。我们的研究结果表明，耐药转移到肺预测潜在的疾病进展到骨结直肠癌人群比肝转移。
It is well recognized that colorectal cancer does not frequently metastasize to bone. The aim of this retrospective study was to establish whether colorectal cancer ever bypasses other organs and metastasizes directly to bone and whether the presence of lung lesions is superior to liver as a better predictor of the likelihood and timing of bone metastasis. We performed a retrospective analysis on patients with a clinical diagnosis of colon cancer referred for staging using whole-body 18F-FDG PET and CT or PET/CT. We combined PET and CT reports from 252 individuals with information concerning patient history, other imaging modalities, and treatments to analyze disease progression. No patient had isolated osseous metastasis at the time of diagnosis, and none developed isolated bone metastasis without other organ involvement during our survey period. It took significantly longer for colorectal cancer patients to develop metastasis to the lungs (23.3 months) or to bone (21.2 months) than to the liver (9.8 months). Conclusion: Metastasis only to bone without other organ involvement in colorectal cancer patients is extremely rare, perhaps more rare than we previously thought. Our findings suggest that resistant metastasis to the lungs predicts potential disease progression to bone in the colorectal cancer population better than liver metastasis does.
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