Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.
Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.
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海胆幼虫的伤口修复涉及色素细胞和胚泡细胞。
DOI：
10.1016/j.ydbio.2022.08.005
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发表时间：
2022-11
影响因子：
2.7
通讯作者：
McClay, David R.
中科院分区：
文献类型：
--
作者：
Allen, Raymond L.;George, Andrew N.;Miranda, Esther;Phillips, Taji M.;Crawford, Janice M.;Kiehart, Daniel P.;McClay, David R.
海胆幼虫在变态前要花几个星期到几个月的时间以浮游生物为食。当在实验室中处理时，它们很容易受伤，这表明在浮游生物中，它们以一定的频率受伤。幸运的是，幼虫的伤口是通过有效的伤口反应与间充质色素细胞和囊胚腔细胞协助上皮关闭修复。在诱导伤口的几秒钟内，由伤口引发的钙瞬变迅速扩散到整个幼虫周围，并且是激活色素细胞向伤口迁移所必需的。如果钙转运受阻，色素细胞就不能激活并保持原位。当被激活时，色素细胞立即启动从至少85μm的距离向伤口部位的定向迁移。到达伤口部位后，它们参与先天免疫反应。囊胚腔细胞也被募集到损伤部位，尽管钙瞬变对于激活这些细胞是不必要的。在伤口部位，囊胚腔细胞参与几种功能，包括重塑骨骼，如果它突出通过上皮。
Sea urchin larvae spend weeks to months feeding on plankton prior to metamorphosis. When handled in the laboratory they are easily injured, suggesting that in the plankton they are injured with some frequency. Fortunately, larval wounds are repaired through an efficient wound response with mesenchymal pigment cells and blastocoelar cells assisting as the epithelium closes. Within seconds of an induced wound a calcium transient, initiated by the wound, rapidly spreads around the entire larva and is necessary for activating pigment cell migration toward the wound. If calcium transport is blocked, the pigment cells fail to activate and remain in place. When activated, pigment cells immediately initiate directed migration to the wound site from distances of at least 85μm. Upon arrival at the wound site they participate in an innate immune response. Blastocoelar cells are recruited to the injury site as well, though the calcium transient is unnecessary for activating these cells. At the wound site, blastocoelar cells participate in several functions including remodeling the skeleton if it protrudes through the epithelium.
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影响因子：
7.8
作者：
Eisen, A;Kiehart, D P;Wieland, S J;Reynolds, G T
通讯作者：
Reynolds, G T
DOI：
10.1073/pnas.1205834109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Bollig, Nadine;Bruestle, Anne;Lohoff, Michael
通讯作者：
Lohoff, Michael
DOI：
10.1007/978-3-319-92486-1_22
发表时间：
2018-01-01
期刊：
MARINE ORGANISMS AS MODEL SYSTEMS IN BIOLOGY AND MEDICINE
影响因子：
--
作者：
Calestani, Cristina;Wessel, Gary M.
通讯作者：
Wessel, Gary M.
影响因子：
3.4
作者：
Becker, Pierre T.;Egea, Emilie;Eeckhaut, Igor
通讯作者：
Eeckhaut, Igor
影响因子：
8.7
作者：
Biswas PS;Bhagat G;Pernis AB
通讯作者：
Pernis AB