IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?
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DOI：
10.1111/j.0105-2896.2009.00864.x
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发表时间：
2010-01
影响因子：
8.7
通讯作者：
Pernis AB
中科院分区：
文献类型：
--
作者：
Biswas PS;Bhagat G;Pernis AB
来自小鼠和人类研究的累积证据支持白细胞介素-17（IL-17）和IL-21在炎性关节炎的发病机制中的关键作用。IL-17和IL-21产生的途径和分子机制正在迅速阐明。本文综述了干扰素调节因子4（IRF 4），IRF家族转录因子的成员，已成为IL-17和IL-21产生的关键控制器。我们首先概述了IRF 4在CD 4 + T细胞功能中的复杂作用，然后讨论了我们实验室最近的研究，这些研究揭示了Rho鸟苷三磷酸酶介导的通路组分在控制IRF 4活性中的惊人作用。更好地了解这些新的途径将有望为炎症性关节炎的发展机制提供新的见解，并可能指导新的治疗方法的设计。
Accumulating evidence from murine and human studies supports a key role for interleukin-17 (IL-17) and IL-21 in the pathogenesis of inflammatory arthritis. The pathways and molecular mechanisms that underlie the production of IL-17 and IL-21 are being rapidly elucidated. This review focuses on interferon regulatory factor 4 (IRF4), a member of the IRF family of transcription factors, which has emerged as a crucial controller of both IL-17 and IL-21 production. We first outline the complex role of IRF4 in the function of CD4+ T cells and then discuss recent studies from our laboratory that have revealed a surprising role for components of Rho guanosine triphosphatase-mediated pathways in controlling the activity of IRF4. A better understanding of these novel pathways will hopefully provide new insights into mechanisms responsible for the development of inflammatory arthritis and potentially guide the design of novel therapeutic approaches.
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影响因子：
11.4
作者：
Brass, AL;Zhu, AQ;Singh, H
通讯作者：
Singh, H
影响因子：
30.5
作者：
Doreau, Agnes;Belot, Alexandre;Bonnefoy-Berard, Nathalie
通讯作者：
Bonnefoy-Berard, Nathalie
影响因子：
15.9
作者：
Becart, Stephane;Charvet, Celine;Altman, Amnon
通讯作者：
Altman, Amnon
DOI：
10.1073/pnas.0902745106
发表时间：
2009-04-28
影响因子：
11.1
作者：
Ben-Sasson, Shlomo Z.;Hu-Li, Jane;Paul, William E.
通讯作者：
Paul, William E.
影响因子：
32.4
作者：
Cannon, JL;Labno, CM;Burkhardt, JK
通讯作者：
Burkhardt, JK