The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.
The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.
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非典型的抗抑郁药米物氮平可减轻吗啡诱导的位置偏好和运动敏化的表达。
DOI：
10.1016/j.brainres.2012.07.007
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发表时间：
2012-09-07
期刊：
影响因子：
2.9
通讯作者：
Napier TC
中科院分区：
文献类型：
--
作者：
Graves SM;Persons AL;Riddle JL;Napier TC
Opioid abuse and dependence remains prevalent despite having multiple FDA-approved medications to help maintain abstinence. Mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission. As monoamines are indirectly altered by opioids, the current investigation assessed the ability of mirtazapine to ameliorate morphine-induced behaviors. Conditioned place preference (CPP) is a behavioral assay wherein a rewarding drug is paired with a distinct environmental context resulting in reward-related salience of cues through learning-related neuronal plasticity. A second behavioral assay involved motor sensitization (MSn), wherein repeated administration results in an enhanced motoric response to an acute challenge, also reflecting neuronal plasticity. Attenuation of CPP and/or MSn provides two behavioral measures to suggest therapeutic potential for addiction therapy, and the present study evaluated the effectiveness of mirtazapine to reduce both behaviors. To do so, morphine-induced CPP was established using an eight day conditioning paradigm, and expression of CPP was tested on day 10 following a 24hr or 30min mirtazapine pretreatment. To determine if mirtazapine altered the expression of MSn, on Day 11, rats received a pretreatment of mirtazapine, followed 30min later by a challenge injection of morphine. Pretreatment with mirtazapine 24hr prior to the CPP test had no effect on CPP expression. In contrast, a 30min pretreatment of mirtazapine attenuated the expression of both CPP and MSn. Collectively, these results indicate that mirtazapine may help to maintain abstinence in opioid dependent patients.
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影响因子：
2.7
作者：
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通讯作者：
Li, Jing
影响因子：
3.8
作者：
Chiu, CT;Ma, TG;Ho, IK
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Mirtazapine改变了在大鼠中寻求与提示相关的甲基苯丙胺。
影响因子：
10.6
作者：
Graves, Steven M.;Napier, T. Celeste
通讯作者：
Napier, T. Celeste
影响因子：
1.7
作者：
Bland, ST;Schmid, MJ;Maier, SF
通讯作者：
Maier, SF
影响因子：
3.4
作者：
Berendsen, HHG;Broekkamp, CLE
通讯作者：
Broekkamp, CLE