Bone Marrow Stem Cells Derived from Nerves Have Neurogenic Properties and Potential Utility for Regenerative Therapy.
Bone Marrow Stem Cells Derived from Nerves Have Neurogenic Properties and Potential Utility for Regenerative Therapy.
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DOI：
10.3390/ijms24065211
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发表时间：
2023-03-08
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
周围神经系统的神经元和神经胶质细胞来源于胚胎神经嵴的祖细胞群。神经嵴和脉管系统在胚胎发育期间和成熟的中枢神经系统中密切相关，其中它们形成由神经元、神经胶质、周细胞和血管内皮细胞组成的神经血管单元，其在健康和疾病中起重要作用。我们的小组和其他人以前曾报道，出生后的干细胞群体来源于神经胶质细胞或许旺细胞具有神经干细胞的品质，包括快速增殖和分化为成熟的神经胶质细胞和神经元。骨髓接受来自周围神经系统的感觉和交感神经支配，并且已知含有髓鞘形成和无髓鞘形成的许旺细胞。在这里，我们描述了一个群体的神经嵴来源的雪旺细胞居住在一个神经血管龛的骨髓与神经纤维。这些许旺细胞可以分离和扩增。它们在体外表现出可塑性，产生的神经干细胞在移植到肠道后表现出神经原性潜能并在体内肠神经系统内形成神经网络。这些细胞代表了用于治疗神经肠疾病的自体神经干细胞的新来源。
Neurons and glia of the peripheral nervous system are derived from progenitor cell populations, originating from embryonic neural crest. The neural crest and vasculature are intimately associated during embryonic development and in the mature central nervous system, in which they form a neurovascular unit comprised of neurons, glia, pericytes, and vascular endothelial cells that play important roles in health and disease. Our group and others have previously reported that postnatal populations of stem cells originating from glia or Schwann cells possess neural stem cell qualities, including rapid proliferation and differentiation into mature glia and neurons. Bone marrow receives sensory and sympathetic innervation from the peripheral nervous system and is known to contain myelinating and unmyelinating Schwann cells. Herein, we describe a population of neural crest-derived Schwann cells residing in a neurovascular niche of bone marrow in association with nerve fibers. These Schwann cells can be isolated and expanded. They demonstrate plasticity in vitro, generating neural stem cells that exhibit neurogenic potential and form neural networks within the enteric nervous system in vivo following transplantation to the intestine. These cells represent a novel source of autologous neural stem cells for the treatment of neurointestinal disorders.
影响因子：
4.3
作者：
Mueller, Jessica L.;Stavely, Rhian;Hotta, Ryo;Goldstein, Allan M.
通讯作者：
Goldstein, Allan M.
DOI：
10.1084/jem.20102187
发表时间：
2011-05-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kubota Y;Takubo K;Hirashima M;Nagoshi N;Kishi K;Okuno Y;Nakamura-Ishizu A;Sano K;Murakami M;Ema M;Omatsu Y;Takahashi S;Nagasawa T;Shibuya M;Okano H;Suda T
通讯作者：
Suda T
影响因子：
19
作者：
Gelfand, Maria V.;Hong, Shangyu;Gu, Chenghua
通讯作者：
Gu, Chenghua