NK gene complex dynamics and selection for NK cell receptors.

NK gene complex dynamics and selection for NK cell receptors.
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DOI:
10.1016/j.smim.2008.06.004
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发表时间:
2008-12
影响因子:
7.8
通讯作者:
Scalzo AA
Scalzo AA
中科院分区:
医学2区
文献类型:
--
作者:
Brown MG;Scalzo AA

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自然杀伤(NK)细胞在对抗感染因子特别是病毒和肿瘤的先天防御中起重要作用。它们通过直接细胞溶解、释放细胞因子和调节随后的适应性免疫应答来介导其作用。NK细胞配备有复杂的抑制和激活受体阵列,调节其功能。在这篇综述中,我们阐述了不同动物物种之间NK细胞受体之间的一些主要进化关系,以及引起受体家族这种多样性的一些主要机制,包括病毒等病原体在驱动受体方面的潜在作用。进化。
Natural Killer (NK) cells play important roles in innate defense against infectious agents particularly viruses and also tumors. They mediate their effects through direct cytolysis, release of cytokines and regulation of subsequent adaptive immune responses. NK cells are equipped with sophisticated arrays of inhibitory and activation receptors that regulate their function. In this review we illustrate some of the major evolutionary relationships between NK cell receptors among different animal species and what some of the major mechanisms are that give rise to this diversity in receptor families, including the potential roles of pathogens such as viruses in driving receptor evolution.
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